Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating disease

Myelin-specific, pro-inflammatory TH17 cells are widely regarded as the drivers of experimental autoimmune encephalomyelitis (EAE), an animal model for Multiple sclerosis (MS). The factors, responsible for the generation and maintenance of TH17 cells as well as their participation in the pathogenic...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e87876-e87876
Hauptverfasser:	Berer, Kerstin, Boziki, Marina, Krishnamoorthy, Gurumoorthy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies Antigen-Presenting Cells - immunology Antigens Autoimmune diseases Autoimmunity B cells Biology Cytokines Demyelinating Autoimmune Diseases, CNS - genetics Demyelinating Autoimmune Diseases, CNS - immunology Demyelination Digestive system Digestive tract Disease Disease Models, Animal Disease resistance Disease Resistance - genetics Disease Resistance - immunology Disease susceptibility Encephalomyelitis, Autoimmune, Experimental - immunology Experimental allergic encephalomyelitis Gastrointestinal tract Genetic engineering Helper cells Histocompatibility Antigens Class II - immunology Homing Immunization Immunology Integrins - metabolism Intestine Intestines - immunology Intestines - metabolism Lymphatic system Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Lymphoid Tissue - immunology Medicine Mice Mice, Transgenic Microbiota Multiple sclerosis Myelin Myelin-Oligodendrocyte Glycoprotein - immunology Neurobiology Neurosciences Organs Pathogenesis Receptors, Antigen, T-Cell - genetics Rodents Small intestine T cell receptors T cells T-Cell Antigen Receptor Specificity - immunology T-cell receptor T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Th17 Cells - immunology Transgenic mice
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