Vaccination of mice using the West Nile virus E-protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects mice against a lethal challenge

West Nile virus (WNV) is a mosquito-borne flavivirus that is endemic in Africa, the Middle East, Europe and the United States. There is currently no antiviral treatment or human vaccine available to treat or prevent WNV infection. DNA plasmid-based vaccines represent a new approach for controlling i...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e87837
Hauptverfasser:	De Filette, Marina, Soehle, Silke, Ulbert, Sebastian, Richner, Justin, Diamond, Michael S, Sinigaglia, Alessandro, Barzon, Luisa, Roels, Stefan, Lisziewicz, Julianna, Lorincz, Orsolya, Sanders, Niek N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Specificity - immunology Antigens Antiviral agents Aquatic insects Biology CD8 antigen Cell-mediated immunity Chemistry Cytometry Cytotoxicity Dendritic cells Deoxyribonucleic acid Disease control DNA DNA vaccines Encephalitis Enzyme-linked immunosorbent assay Female Flow cytometry Gene therapy Genetic vectors Homology Immune response (humoral) Immunity Immunity, Cellular Immunization Immunization, Secondary Immunology Infection Infections Infectious diseases Influenza Interferon Interleukin 4 Laboratories Lymphocytes B Lymphocytes T Mannose Medical research Medicine Mice Monosaccharides Nanoparticles Nanoparticles - chemistry Plasmids Polyethyleneimine Proteins Public health Rodents T cells Th2 Cells - immunology Vaccination Vaccines Vaccines, DNA Vector-borne diseases Veterinary Science Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Virology Viruses West Nile fever West Nile Fever - immunology West Nile Fever - mortality West Nile Fever - prevention & control West Nile virus West Nile virus - genetics West Nile virus - immunology West Nile Virus Vaccines - adverse effects West Nile Virus Vaccines - immunology γ-Interferon
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