Impaired dynamic cerebral autoregulation and cerebrovascular reactivity in middle cerebral artery stenosis
We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis. Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulati...
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| creator | Chen, Jie Liu, Jia Xu, Wei-Hai Xu, Ren Hou, Bo Cui, Li-Ying Gao, Shan |
| description | We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis.
Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulation was assessed by autoregulatory parameters (rate of recovery/phase/gain) derived from transfer function from spontaneous oscillations of cerebral blood flow velocity and blood pressure. CVR was tested by a rebreathing maneuver.
Rate of recovery, phase and CVR estimated from moderate MCA stenosis (rate of recovery = 17.76 ± 8.21%/s, phase = 26.93 ± 15.67°, and CVR = 1.53 ± 0.84%/mmHg, respectively) were significantly different (p |
| doi_str_mv | 10.1371/journal.pone.0088232 |
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Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulation was assessed by autoregulatory parameters (rate of recovery/phase/gain) derived from transfer function from spontaneous oscillations of cerebral blood flow velocity and blood pressure. CVR was tested by a rebreathing maneuver.
Rate of recovery, phase and CVR estimated from moderate MCA stenosis (rate of recovery = 17.76 ± 8.21%/s, phase = 26.93 ± 15.67°, and CVR = 1.53 ± 0.84%/mmHg, respectively) were significantly different (p<0.05) from controls (rate of recovery = 39.62 ± 27.99%/s, phase = 55.66 ± 22.10°, and CVR = 2.18 ± 0.80%/mmHg, respectively). Rate of recovery (r = -0.698, p<0.001), phase (r = -0.738, p<0.001)) and CVR (r = -0.690, p<0.001) were all significantly correlated with the degree of stenosis.
Cerebral autoregulation and CVR were impaired in patients with ≥ 50% MCA stenosis. The measures of both hemodynamic properties were inversely correlated with the stenotic degree.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0088232</identifier><identifier>PMID: 24505442</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Angiography ; Biology ; Blood ; Blood flow ; Blood Flow Velocity - physiology ; Blood pressure ; Blood Pressure - physiology ; Carbon dioxide ; Carotid arteries ; Carotid Stenosis - physiopathology ; Cerebral blood flow ; Cerebral Cortex - physiopathology ; Cerebrovascular Circulation - physiology ; Cerebrovascular system ; Female ; Flow velocity ; Hemodynamics ; Hemodynamics - physiology ; Homeostasis - physiology ; Hospitals ; Humans ; Hypertension ; Magnetic resonance ; Male ; Measurement techniques ; Medical imaging ; Medical research ; Medicine ; Middle Aged ; Middle Cerebral Artery - physiopathology ; Neurology ; Oscillations ; Patients ; Physiology ; Rebreathing ; Recovery ; Stenosis ; Stroke ; Studies ; Transfer functions ; Veins & arteries</subject><ispartof>PloS one, 2014-02, Vol.9 (2), p.e88232-e88232</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Chen et al 2014 Chen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-62530a98bd8d4e1186baa9d4580425b589c3bf241decbcff6c1a53a73150a62c3</citedby><cites>FETCH-LOGICAL-c692t-62530a98bd8d4e1186baa9d4580425b589c3bf241decbcff6c1a53a73150a62c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913771/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913771/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24505442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hendrikse, Jeroen</contributor><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Liu, Jia</creatorcontrib><creatorcontrib>Xu, Wei-Hai</creatorcontrib><creatorcontrib>Xu, Ren</creatorcontrib><creatorcontrib>Hou, Bo</creatorcontrib><creatorcontrib>Cui, Li-Ying</creatorcontrib><creatorcontrib>Gao, Shan</creatorcontrib><title>Impaired dynamic cerebral autoregulation and cerebrovascular reactivity in middle cerebral artery stenosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis.
Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulation was assessed by autoregulatory parameters (rate of recovery/phase/gain) derived from transfer function from spontaneous oscillations of cerebral blood flow velocity and blood pressure. CVR was tested by a rebreathing maneuver.
Rate of recovery, phase and CVR estimated from moderate MCA stenosis (rate of recovery = 17.76 ± 8.21%/s, phase = 26.93 ± 15.67°, and CVR = 1.53 ± 0.84%/mmHg, respectively) were significantly different (p<0.05) from controls (rate of recovery = 39.62 ± 27.99%/s, phase = 55.66 ± 22.10°, and CVR = 2.18 ± 0.80%/mmHg, respectively). Rate of recovery (r = -0.698, p<0.001), phase (r = -0.738, p<0.001)) and CVR (r = -0.690, p<0.001) were all significantly correlated with the degree of stenosis.
Cerebral autoregulation and CVR were impaired in patients with ≥ 50% MCA stenosis. The measures of both hemodynamic properties were inversely correlated with the stenotic degree.</description><subject>Angiography</subject><subject>Biology</subject><subject>Blood</subject><subject>Blood flow</subject><subject>Blood Flow Velocity - physiology</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Carbon dioxide</subject><subject>Carotid arteries</subject><subject>Carotid Stenosis - physiopathology</subject><subject>Cerebral blood flow</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cerebrovascular system</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Hemodynamics</subject><subject>Hemodynamics - physiology</subject><subject>Homeostasis - physiology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Magnetic resonance</subject><subject>Male</subject><subject>Measurement techniques</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Middle Cerebral Artery - physiopathology</subject><subject>Neurology</subject><subject>Oscillations</subject><subject>Patients</subject><subject>Physiology</subject><subject>Rebreathing</subject><subject>Recovery</subject><subject>Stenosis</subject><subject>Stroke</subject><subject>Studies</subject><subject>Transfer functions</subject><subject>Veins & arteries</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0trGzEQx5fS0qRpv0FpFwqlPdjVa2XpUgihD0Mg0NdVzEpaW2Z35UpaU3_7yvEmeEsORQeJ0W_-mhnNFMVLjOaYLvCHjR9CD-1863s7R0gIQsmj4hxLSmacIPr45HxWPItxg1BFBedPizPCKlQxRs6LzbLbggvWlGbfQ-d0qW2wdYC2hCH5YFdDC8n5voTejHd-B1FncyiDBZ3czqV96fqyc8a09kQgJBv2ZUy299HF58WTBtpoX4z7RfHz86cfV19n1zdflleX1zPNJUk53ooikKI2wjCLseA1gDSsEoiRqq6E1LRuCMPG6lo3DdcYKgoLiisEnGh6Ubw-6m5bH9VYpqgwk4xKKSjKxPJIGA8btQ2ug7BXHpy6NfiwUjl2p1urBDGcC75ojKyYIULWmhOua0RxQ4mlWevj-NpQd9Zo26ec-0R0etO7tVr5naIyf-MCZ4F3o0Dwvwcbk-pc1LZtobd-uI07k4yhA_rmH_Th7EZqBTkB1zc-v6sPouqSLYSgGMtFpuYPUHkZm7sg91Tjsn3i8H7ikJlk_6QVDDGq5fdv_8_e_Jqyb0_YtYU2raNvh0PTxSnIjqAOPsZgm_siY6QOI3FXDXUYCTWORHZ7dfpB9053M0D_AlNlB_0</recordid><startdate>20140204</startdate><enddate>20140204</enddate><creator>Chen, Jie</creator><creator>Liu, Jia</creator><creator>Xu, Wei-Hai</creator><creator>Xu, Ren</creator><creator>Hou, Bo</creator><creator>Cui, Li-Ying</creator><creator>Gao, Shan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140204</creationdate><title>Impaired dynamic cerebral autoregulation and cerebrovascular reactivity in middle cerebral artery stenosis</title><author>Chen, Jie ; Liu, Jia ; Xu, Wei-Hai ; Xu, Ren ; Hou, Bo ; Cui, Li-Ying ; Gao, Shan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-62530a98bd8d4e1186baa9d4580425b589c3bf241decbcff6c1a53a73150a62c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Angiography</topic><topic>Biology</topic><topic>Blood</topic><topic>Blood flow</topic><topic>Blood Flow Velocity - physiology</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Carbon dioxide</topic><topic>Carotid arteries</topic><topic>Carotid Stenosis - physiopathology</topic><topic>Cerebral blood flow</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cerebrovascular system</topic><topic>Female</topic><topic>Flow velocity</topic><topic>Hemodynamics</topic><topic>Hemodynamics - physiology</topic><topic>Homeostasis - physiology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Magnetic resonance</topic><topic>Male</topic><topic>Measurement techniques</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Middle Cerebral Artery - physiopathology</topic><topic>Neurology</topic><topic>Oscillations</topic><topic>Patients</topic><topic>Physiology</topic><topic>Rebreathing</topic><topic>Recovery</topic><topic>Stenosis</topic><topic>Stroke</topic><topic>Studies</topic><topic>Transfer functions</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Liu, Jia</creatorcontrib><creatorcontrib>Xu, Wei-Hai</creatorcontrib><creatorcontrib>Xu, Ren</creatorcontrib><creatorcontrib>Hou, Bo</creatorcontrib><creatorcontrib>Cui, Li-Ying</creatorcontrib><creatorcontrib>Gao, Shan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Science In Context</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jie</au><au>Liu, Jia</au><au>Xu, Wei-Hai</au><au>Xu, Ren</au><au>Hou, Bo</au><au>Cui, Li-Ying</au><au>Gao, Shan</au><au>Hendrikse, Jeroen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired dynamic cerebral autoregulation and cerebrovascular reactivity in middle cerebral artery stenosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-02-04</date><risdate>2014</risdate><volume>9</volume><issue>2</issue><spage>e88232</spage><epage>e88232</epage><pages>e88232-e88232</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis.
Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulation was assessed by autoregulatory parameters (rate of recovery/phase/gain) derived from transfer function from spontaneous oscillations of cerebral blood flow velocity and blood pressure. CVR was tested by a rebreathing maneuver.
Rate of recovery, phase and CVR estimated from moderate MCA stenosis (rate of recovery = 17.76 ± 8.21%/s, phase = 26.93 ± 15.67°, and CVR = 1.53 ± 0.84%/mmHg, respectively) were significantly different (p<0.05) from controls (rate of recovery = 39.62 ± 27.99%/s, phase = 55.66 ± 22.10°, and CVR = 2.18 ± 0.80%/mmHg, respectively). Rate of recovery (r = -0.698, p<0.001), phase (r = -0.738, p<0.001)) and CVR (r = -0.690, p<0.001) were all significantly correlated with the degree of stenosis.
Cerebral autoregulation and CVR were impaired in patients with ≥ 50% MCA stenosis. The measures of both hemodynamic properties were inversely correlated with the stenotic degree.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24505442</pmid><doi>10.1371/journal.pone.0088232</doi><tpages>e88232</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angiography Biology Blood Blood flow Blood Flow Velocity - physiology Blood pressure Blood Pressure - physiology Carbon dioxide Carotid arteries Carotid Stenosis - physiopathology Cerebral blood flow Cerebral Cortex - physiopathology Cerebrovascular Circulation - physiology Cerebrovascular system Female Flow velocity Hemodynamics Hemodynamics - physiology Homeostasis - physiology Hospitals Humans Hypertension Magnetic resonance Male Measurement techniques Medical imaging Medical research Medicine Middle Aged Middle Cerebral Artery - physiopathology Neurology Oscillations Patients Physiology Rebreathing Recovery Stenosis Stroke Studies Transfer functions Veins & arteries |
| title | Impaired dynamic cerebral autoregulation and cerebrovascular reactivity in middle cerebral artery stenosis |
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