c-Myc regulates cell proliferation during lens development

Myc protooncogenes play important roles in the regulation of cell proliferation, growth, differentiation and survival during development. In various developing organs, c-myc has been shown to control the expression of cell cycle regulators and its misregulated expression is detected in many human tu...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e87182
Hauptverfasser:	Cavalheiro, Gabriel R, Matos-Rodrigues, Gabriel E, Gomes, Anielle L, Rodrigues, Paulo M G, Martins, Rodrigo A P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Auditory defects Biology c-Myc protein Cell cycle Cell death Cell Differentiation Cell growth Cell Proliferation Cell Survival Cells (biology) Clonal deletion Crystallins - metabolism Cyclin-dependent kinase inhibitor p27 Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cyclin-dependent kinases Deactivation Developmental biology Ectoderm Ectoderm - cytology Ectoderm - growth & development Ectopic expression Epithelial cells Epithelial Cells - cytology Forkhead protein Forkhead Transcription Factors - metabolism Gene deletion Gene expression Gene Expression Regulation, Developmental Gene Silencing Growth factors Homeodomain Proteins - metabolism Inactivation Kinases Lens, Crystalline - cytology Lens, Crystalline - embryology Lenses Medicine Mice Myc protein Organogenesis Organs Phenotype Physiological aspects Progenitor cells Proteins Proto-Oncogene Proteins c-myc - deficiency Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Regulators Rodents Stem cells Studies Transcription factors Tumor Suppressor Proteins - metabolism Tumors
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