Dominant effects of the diet on the microbiome and the local and systemic immune response in mice
Outside the nutrition community the effects of diet on immune-mediated diseases and experimental outcomes have not been appreciated. Investigators that study immune-mediated diseases and/or the microbiome have overlooked the potential of diet to impact disease phenotype. We aimed to determine the ef...
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| description | Outside the nutrition community the effects of diet on immune-mediated diseases and experimental outcomes have not been appreciated. Investigators that study immune-mediated diseases and/or the microbiome have overlooked the potential of diet to impact disease phenotype. We aimed to determine the effects of diet on the bacterial microbiota and immune-mediated diseases. Three different laboratory diets were fed to wild-type mice for 2 weeks and resulted in three distinct susceptibilities to dextran sodium sulfate (DSS)-induced colitis. Examination of the fecal microbiota demonstrated a diet-mediated effect on the bacteria found there. Broad-spectrum antibiotics disturbed the gut microbiome and partially eliminated the diet-mediated changes in DSS susceptibility. Dietary changes 2 days after DSS treatment were protective and suggested that the diet-mediated effect occurred quickly. There were no diet-mediated effects on DSS susceptibility in germ-free mice. In addition, the diet-mediated effects were evident in a gastrointestinal infection model (Citrobacter rodentium) and in experimental autoimmune encephalomyelitis. Taken together, our study demonstrates a dominant effect of diet on immune-mediated diseases that act rapidly by changing the microbiota. These findings highlight the potential of using dietary manipulation to control the microbiome and prevent/treat immune-mediated disease. |
| doi_str_mv | 10.1371/journal.pone.0086366 |
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Investigators that study immune-mediated diseases and/or the microbiome have overlooked the potential of diet to impact disease phenotype. We aimed to determine the effects of diet on the bacterial microbiota and immune-mediated diseases. Three different laboratory diets were fed to wild-type mice for 2 weeks and resulted in three distinct susceptibilities to dextran sodium sulfate (DSS)-induced colitis. Examination of the fecal microbiota demonstrated a diet-mediated effect on the bacteria found there. Broad-spectrum antibiotics disturbed the gut microbiome and partially eliminated the diet-mediated changes in DSS susceptibility. Dietary changes 2 days after DSS treatment were protective and suggested that the diet-mediated effect occurred quickly. There were no diet-mediated effects on DSS susceptibility in germ-free mice. In addition, the diet-mediated effects were evident in a gastrointestinal infection model (Citrobacter rodentium) and in experimental autoimmune encephalomyelitis. Taken together, our study demonstrates a dominant effect of diet on immune-mediated diseases that act rapidly by changing the microbiota. These findings highlight the potential of using dietary manipulation to control the microbiome and prevent/treat immune-mediated disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0086366</identifier><identifier>PMID: 24489720</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Antibiotics ; Bacteria ; Biochemistry ; Biology ; Citrobacter ; Citrobacter rodentium - physiology ; Colitis ; Colitis - chemically induced ; Colitis - diet therapy ; Colitis - immunology ; Colitis - microbiology ; Crohn's disease ; Crohns disease ; Cytokines ; Dextran ; Dextran Sulfate ; Dextrans ; Diet ; Disease control ; Diseases ; Encephalomyelitis, Autoimmune, Experimental - diet therapy ; Encephalomyelitis, Autoimmune, Experimental - immunology ; Encephalomyelitis, Autoimmune, Experimental - microbiology ; Enterobacteriaceae Infections - diet therapy ; Enterobacteriaceae Infections - immunology ; Enterobacteriaceae Infections - microbiology ; Experimental allergic encephalomyelitis ; Experiments ; Fecal microflora ; Feces - microbiology ; Female ; Gastrointestinal Tract - immunology ; Gastrointestinal Tract - microbiology ; Germ-Free Life - immunology ; Germfree ; Immune response ; Immune system ; Immunology ; Infectious diseases ; Inflammatory bowel disease ; Intestinal microflora ; Laboratories ; Lactose ; Male ; Medical research ; Medicine ; Mice ; Microbiota ; Microbiota (Symbiotic organisms) ; Microbiota - immunology ; Molecular biology ; Multiple sclerosis ; Nutrition ; Rodents ; Science ; Sodium ; Sodium sulfate ; Sulfates ; Vitamin D</subject><ispartof>PloS one, 2014-01, Vol.9 (1), p.e86366</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Ooi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Ooi et al 2014 Ooi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3c9b4a4b0e8c0b2dd79bff464a034f8525a8a7c424dffbaba35abc1878bb30aa3</citedby><cites>FETCH-LOGICAL-c692t-3c9b4a4b0e8c0b2dd79bff464a034f8525a8a7c424dffbaba35abc1878bb30aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906035/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906035/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24489720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ooi, Jot Hui</creatorcontrib><creatorcontrib>Waddell, Amanda</creatorcontrib><creatorcontrib>Lin, Yang-Ding</creatorcontrib><creatorcontrib>Albert, Istvan</creatorcontrib><creatorcontrib>Rust, Laura T</creatorcontrib><creatorcontrib>Holden, Victoria</creatorcontrib><creatorcontrib>Cantorna, Margherita T</creatorcontrib><title>Dominant effects of the diet on the microbiome and the local and systemic immune response in mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Outside the nutrition community the effects of diet on immune-mediated diseases and experimental outcomes have not been appreciated. Investigators that study immune-mediated diseases and/or the microbiome have overlooked the potential of diet to impact disease phenotype. We aimed to determine the effects of diet on the bacterial microbiota and immune-mediated diseases. Three different laboratory diets were fed to wild-type mice for 2 weeks and resulted in three distinct susceptibilities to dextran sodium sulfate (DSS)-induced colitis. Examination of the fecal microbiota demonstrated a diet-mediated effect on the bacteria found there. Broad-spectrum antibiotics disturbed the gut microbiome and partially eliminated the diet-mediated changes in DSS susceptibility. Dietary changes 2 days after DSS treatment were protective and suggested that the diet-mediated effect occurred quickly. There were no diet-mediated effects on DSS susceptibility in germ-free mice. In addition, the diet-mediated effects were evident in a gastrointestinal infection model (Citrobacter rodentium) and in experimental autoimmune encephalomyelitis. Taken together, our study demonstrates a dominant effect of diet on immune-mediated diseases that act rapidly by changing the microbiota. These findings highlight the potential of using dietary manipulation to control the microbiome and prevent/treat immune-mediated disease.</description><subject>Analysis</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Biochemistry</subject><subject>Biology</subject><subject>Citrobacter</subject><subject>Citrobacter rodentium - physiology</subject><subject>Colitis</subject><subject>Colitis - chemically induced</subject><subject>Colitis - diet therapy</subject><subject>Colitis - immunology</subject><subject>Colitis - microbiology</subject><subject>Crohn's disease</subject><subject>Crohns disease</subject><subject>Cytokines</subject><subject>Dextran</subject><subject>Dextran Sulfate</subject><subject>Dextrans</subject><subject>Diet</subject><subject>Disease control</subject><subject>Diseases</subject><subject>Encephalomyelitis, Autoimmune, Experimental - diet therapy</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - 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immunology</subject><subject>Molecular biology</subject><subject>Multiple sclerosis</subject><subject>Nutrition</subject><subject>Rodents</subject><subject>Science</subject><subject>Sodium</subject><subject>Sodium sulfate</subject><subject>Sulfates</subject><subject>Vitamin D</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLguDFjGmStumNsKxfAwsLft2Gk_RkJkObjE0q7r83M9NdpqAguUh68rxvDydvlj0vyLJgdfF268fBQbfceYdLQkTFqupBdl40jC4qStjDk_NZ9iSELSElE1X1ODujnIumpuQ8g_e-tw5czNEY1DHk3uRxg3lrMebeHc691YNX1veYg2sPpc5r6A5f4TZETERu-350mA8YUksBc-v2QnyaPTLQBXw27RfZ948fvl19XlzffFpdXV4vdNXQuGC6URy4Iig0UbRt60YZwysOhHEjSlqCgFpzyltjFChgJShdiFooxQgAu8heHn13nQ9ymk6QBW9oySkjIhGrI9F62MrdYHsYbqUHKw8FP6wlDNHqDiUDZoihtVJly6kRjSramiJVSkEjjE5e76a_jarHVqOLA3Qz0_mNsxu59r8ka0hFWJkMXk0Gg_85Yoj_aHmi1pC6ss74ZKZ7G7S85LUQrOQNS9TyL1Ra7f5hUj6MTfWZ4M1MkJiIv-MaxhDk6uuX_2dvfszZ1yfsBqGLm-C7MdqUiDnIj2AKVggDmvvJFUTu4303DbmPt5zinWQvTqd-L7rLM_sDrmj3HQ</recordid><startdate>20140129</startdate><enddate>20140129</enddate><creator>Ooi, Jot Hui</creator><creator>Waddell, Amanda</creator><creator>Lin, Yang-Ding</creator><creator>Albert, Istvan</creator><creator>Rust, Laura T</creator><creator>Holden, Victoria</creator><creator>Cantorna, Margherita T</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140129</creationdate><title>Dominant effects of the diet on the microbiome and the local and systemic immune response in mice</title><author>Ooi, Jot Hui ; Waddell, Amanda ; Lin, Yang-Ding ; Albert, Istvan ; Rust, Laura T ; Holden, Victoria ; Cantorna, Margherita T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3c9b4a4b0e8c0b2dd79bff464a034f8525a8a7c424dffbaba35abc1878bb30aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Biochemistry</topic><topic>Biology</topic><topic>Citrobacter</topic><topic>Citrobacter rodentium - 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Investigators that study immune-mediated diseases and/or the microbiome have overlooked the potential of diet to impact disease phenotype. We aimed to determine the effects of diet on the bacterial microbiota and immune-mediated diseases. Three different laboratory diets were fed to wild-type mice for 2 weeks and resulted in three distinct susceptibilities to dextran sodium sulfate (DSS)-induced colitis. Examination of the fecal microbiota demonstrated a diet-mediated effect on the bacteria found there. Broad-spectrum antibiotics disturbed the gut microbiome and partially eliminated the diet-mediated changes in DSS susceptibility. Dietary changes 2 days after DSS treatment were protective and suggested that the diet-mediated effect occurred quickly. There were no diet-mediated effects on DSS susceptibility in germ-free mice. In addition, the diet-mediated effects were evident in a gastrointestinal infection model (Citrobacter rodentium) and in experimental autoimmune encephalomyelitis. Taken together, our study demonstrates a dominant effect of diet on immune-mediated diseases that act rapidly by changing the microbiota. These findings highlight the potential of using dietary manipulation to control the microbiome and prevent/treat immune-mediated disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24489720</pmid><doi>10.1371/journal.pone.0086366</doi><tpages>e86366</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-01, Vol.9 (1), p.e86366 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1492542308 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analysis Animals Antibiotics Bacteria Biochemistry Biology Citrobacter Citrobacter rodentium - physiology Colitis Colitis - chemically induced Colitis - diet therapy Colitis - immunology Colitis - microbiology Crohn's disease Crohns disease Cytokines Dextran Dextran Sulfate Dextrans Diet Disease control Diseases Encephalomyelitis, Autoimmune, Experimental - diet therapy Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - microbiology Enterobacteriaceae Infections - diet therapy Enterobacteriaceae Infections - immunology Enterobacteriaceae Infections - microbiology Experimental allergic encephalomyelitis Experiments Fecal microflora Feces - microbiology Female Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Germ-Free Life - immunology Germfree Immune response Immune system Immunology Infectious diseases Inflammatory bowel disease Intestinal microflora Laboratories Lactose Male Medical research Medicine Mice Microbiota Microbiota (Symbiotic organisms) Microbiota - immunology Molecular biology Multiple sclerosis Nutrition Rodents Science Sodium Sodium sulfate Sulfates Vitamin D |
| title | Dominant effects of the diet on the microbiome and the local and systemic immune response in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T17%3A17%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dominant%20effects%20of%20the%20diet%20on%20the%20microbiome%20and%20the%20local%20and%20systemic%20immune%20response%20in%20mice&rft.jtitle=PloS%20one&rft.au=Ooi,%20Jot%20Hui&rft.date=2014-01-29&rft.volume=9&rft.issue=1&rft.spage=e86366&rft.pages=e86366-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0086366&rft_dat=%3Cgale_plos_%3EA478835493%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1492542308&rft_id=info:pmid/24489720&rft_galeid=A478835493&rft_doaj_id=oai_doaj_org_article_3a3f0f27bb5d42f89b1d72e2bbba98fc&rfr_iscdi=true |