Chronic oxidative stress increases growth and tumorigenic potential of MCF-7 breast cancer cells

Accumulating evidence suggests that exposures to elevated levels of either endogenous estrogen or environmental estrogenic chemicals are associated with breast cancer development and progression. These natural or synthetic estrogens are known to produce reactive oxygen species (ROS) and increased RO...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e87371
Hauptverfasser:	Mahalingaiah, Prathap Kumar S, Singh, Kamaleshwar P
Format:	Artikel
Sprache:	eng
Schlagworte:	Agar Analysis Antibiotics Apoptosis Biology Breast cancer Cancer Cancer cells Cancer metastasis Cancer research Carcinogenesis Carcinogens CD44 antigen Cell Count Cell cycle Cell Cycle Proteins - genetics Cell growth Cell Proliferation - drug effects Cell survival Cell Survival - genetics Chemoresistance Chemotherapy Chronic exposure Colonies Cytotoxicity Deoxyribonucleic acid Development and progression DNA DNA methylation Drug dosages Drug Resistance, Neoplasm - genetics Drugs E-cadherin Estrogens Exposure Gene expression Gene Expression Profiling Gene regulation Genes Growth Humans Hydrogen Hydrogen peroxide Hydrogen Peroxide - pharmacology MCF-7 Cells Medicine Metabolism Metabolites Metastases Metastasis Oxidative Stress Oxygen PCB Polychlorinated biphenyls Reactive oxygen species Reactive Oxygen Species - pharmacology Rodents Statistics Stem cells Survival Toxicity Toxicology Tumorigenicity Vascular endothelial growth factor Xenoestrogens
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