Structural and diffusion property alterations in unaffected siblings of patients with obsessive-compulsive disorder
Disrupted white matter integrity and abnormal cortical thickness are widely reported in the pathophysiology of obsessive-compulsive disorder (OCD). However, the relationship between alterations in white matter connectivity and cortical thickness in OCD is unclear. In addition, the heritability of th...
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| creator | Peng, Ziwen Shi, Feng Shi, Changzheng Miao, Guodong Yang, Qiong Gao, Wei Wolff, Jason J Chan, Raymond C K Shen, Dinggang |
| description | Disrupted white matter integrity and abnormal cortical thickness are widely reported in the pathophysiology of obsessive-compulsive disorder (OCD). However, the relationship between alterations in white matter connectivity and cortical thickness in OCD is unclear. In addition, the heritability of this relationship is poorly understood. To investigate the relationship of white matter microstructure with cortical thickness, we measure fractional anisotropy (FA) of white matter in 30 OCD patients, 19 unaffected siblings and 30 matched healthy controls. Then, we take those regions of significantly altered FA in OCD patients compared with healthy controls to perform fiber tracking. Next, we calculate the fiber quantity in the same tracts. Lastly, we compare cortical thickness in the target regions of those tracts. Patients with OCD exhibited decreased FA in cingulum, arcuate fibers near the superior parietal lobule, inferior longitudinal fasciculus near the right superior temporal gyrus and uncinate fasciculus. Siblings showed reduced FA in arcuate fibers near the superior parietal lobule and anterior limb of internal capsule. Significant reductions in both fiber quantities and cortical thickness in OCD patients and their unaffected siblings were also observed in the projected brain areas when using the arcuate fibers near the left superior parietal lobule as the starting points. Reduced FA in the left superior parietal lobule was observed not only in patients with OCD but also in their unaffected siblings. Originated from the superior parietal lobule, the number of fibers was also found to be decreased and the corresponding cortical regions were thinner relative to controls. The linkage between disrupted white matter integrity and the abnormal cortical thickness may be a vulnerability marker for OCD. |
| doi_str_mv | 10.1371/journal.pone.0085663 |
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However, the relationship between alterations in white matter connectivity and cortical thickness in OCD is unclear. In addition, the heritability of this relationship is poorly understood. To investigate the relationship of white matter microstructure with cortical thickness, we measure fractional anisotropy (FA) of white matter in 30 OCD patients, 19 unaffected siblings and 30 matched healthy controls. Then, we take those regions of significantly altered FA in OCD patients compared with healthy controls to perform fiber tracking. Next, we calculate the fiber quantity in the same tracts. Lastly, we compare cortical thickness in the target regions of those tracts. Patients with OCD exhibited decreased FA in cingulum, arcuate fibers near the superior parietal lobule, inferior longitudinal fasciculus near the right superior temporal gyrus and uncinate fasciculus. Siblings showed reduced FA in arcuate fibers near the superior parietal lobule and anterior limb of internal capsule. Significant reductions in both fiber quantities and cortical thickness in OCD patients and their unaffected siblings were also observed in the projected brain areas when using the arcuate fibers near the left superior parietal lobule as the starting points. Reduced FA in the left superior parietal lobule was observed not only in patients with OCD but also in their unaffected siblings. Originated from the superior parietal lobule, the number of fibers was also found to be decreased and the corresponding cortical regions were thinner relative to controls. The linkage between disrupted white matter integrity and the abnormal cortical thickness may be a vulnerability marker for OCD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0085663</identifier><identifier>PMID: 24489665</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alterations ; Anisotropy ; Attention deficit hyperactivity disorder ; Biology ; Brain ; Brain Mapping - methods ; Cingulum ; Comparative analysis ; Cortex ; Female ; Fibers ; Heritability ; Humans ; Integrity ; Magnetic Resonance Imaging ; Male ; Medicine ; Neural networks ; Neurosciences ; Obsessive compulsive disorder ; Obsessive-Compulsive Disorder - pathology ; Parietal Lobe - pathology ; Patients ; Siblings ; Studies ; Substantia alba ; Superior parietal lobule ; Superior temporal gyrus ; Temporal gyrus ; Thickness ; Young Adult</subject><ispartof>PloS one, 2014-01, Vol.9 (1), p.e85663-e85663</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Peng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Peng et al 2014 Peng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-76859658a8d955c0eda8c85dbc231dcd7eb9a35e2e52503406397d6b67aa15d93</citedby><cites>FETCH-LOGICAL-c692t-76859658a8d955c0eda8c85dbc231dcd7eb9a35e2e52503406397d6b67aa15d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904847/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904847/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24489665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kassubek, Jan</contributor><creatorcontrib>Peng, Ziwen</creatorcontrib><creatorcontrib>Shi, Feng</creatorcontrib><creatorcontrib>Shi, Changzheng</creatorcontrib><creatorcontrib>Miao, Guodong</creatorcontrib><creatorcontrib>Yang, Qiong</creatorcontrib><creatorcontrib>Gao, Wei</creatorcontrib><creatorcontrib>Wolff, Jason J</creatorcontrib><creatorcontrib>Chan, Raymond C K</creatorcontrib><creatorcontrib>Shen, Dinggang</creatorcontrib><title>Structural and diffusion property alterations in unaffected siblings of patients with obsessive-compulsive disorder</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Disrupted white matter integrity and abnormal cortical thickness are widely reported in the pathophysiology of obsessive-compulsive disorder (OCD). However, the relationship between alterations in white matter connectivity and cortical thickness in OCD is unclear. In addition, the heritability of this relationship is poorly understood. To investigate the relationship of white matter microstructure with cortical thickness, we measure fractional anisotropy (FA) of white matter in 30 OCD patients, 19 unaffected siblings and 30 matched healthy controls. Then, we take those regions of significantly altered FA in OCD patients compared with healthy controls to perform fiber tracking. Next, we calculate the fiber quantity in the same tracts. Lastly, we compare cortical thickness in the target regions of those tracts. Patients with OCD exhibited decreased FA in cingulum, arcuate fibers near the superior parietal lobule, inferior longitudinal fasciculus near the right superior temporal gyrus and uncinate fasciculus. Siblings showed reduced FA in arcuate fibers near the superior parietal lobule and anterior limb of internal capsule. Significant reductions in both fiber quantities and cortical thickness in OCD patients and their unaffected siblings were also observed in the projected brain areas when using the arcuate fibers near the left superior parietal lobule as the starting points. Reduced FA in the left superior parietal lobule was observed not only in patients with OCD but also in their unaffected siblings. Originated from the superior parietal lobule, the number of fibers was also found to be decreased and the corresponding cortical regions were thinner relative to controls. The linkage between disrupted white matter integrity and the abnormal cortical thickness may be a vulnerability marker for OCD.</description><subject>Adult</subject><subject>Alterations</subject><subject>Anisotropy</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Biology</subject><subject>Brain</subject><subject>Brain Mapping - methods</subject><subject>Cingulum</subject><subject>Comparative analysis</subject><subject>Cortex</subject><subject>Female</subject><subject>Fibers</subject><subject>Heritability</subject><subject>Humans</subject><subject>Integrity</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Neural networks</subject><subject>Neurosciences</subject><subject>Obsessive compulsive disorder</subject><subject>Obsessive-Compulsive Disorder - pathology</subject><subject>Parietal Lobe - 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Dinggang</au><au>Kassubek, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural and diffusion property alterations in unaffected siblings of patients with obsessive-compulsive disorder</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-01-28</date><risdate>2014</risdate><volume>9</volume><issue>1</issue><spage>e85663</spage><epage>e85663</epage><pages>e85663-e85663</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Disrupted white matter integrity and abnormal cortical thickness are widely reported in the pathophysiology of obsessive-compulsive disorder (OCD). However, the relationship between alterations in white matter connectivity and cortical thickness in OCD is unclear. In addition, the heritability of this relationship is poorly understood. To investigate the relationship of white matter microstructure with cortical thickness, we measure fractional anisotropy (FA) of white matter in 30 OCD patients, 19 unaffected siblings and 30 matched healthy controls. Then, we take those regions of significantly altered FA in OCD patients compared with healthy controls to perform fiber tracking. Next, we calculate the fiber quantity in the same tracts. Lastly, we compare cortical thickness in the target regions of those tracts. Patients with OCD exhibited decreased FA in cingulum, arcuate fibers near the superior parietal lobule, inferior longitudinal fasciculus near the right superior temporal gyrus and uncinate fasciculus. Siblings showed reduced FA in arcuate fibers near the superior parietal lobule and anterior limb of internal capsule. Significant reductions in both fiber quantities and cortical thickness in OCD patients and their unaffected siblings were also observed in the projected brain areas when using the arcuate fibers near the left superior parietal lobule as the starting points. Reduced FA in the left superior parietal lobule was observed not only in patients with OCD but also in their unaffected siblings. Originated from the superior parietal lobule, the number of fibers was also found to be decreased and the corresponding cortical regions were thinner relative to controls. The linkage between disrupted white matter integrity and the abnormal cortical thickness may be a vulnerability marker for OCD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24489665</pmid><doi>10.1371/journal.pone.0085663</doi><tpages>e85663</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alterations Anisotropy Attention deficit hyperactivity disorder Biology Brain Brain Mapping - methods Cingulum Comparative analysis Cortex Female Fibers Heritability Humans Integrity Magnetic Resonance Imaging Male Medicine Neural networks Neurosciences Obsessive compulsive disorder Obsessive-Compulsive Disorder - pathology Parietal Lobe - pathology Patients Siblings Studies Substantia alba Superior parietal lobule Superior temporal gyrus Temporal gyrus Thickness Young Adult |
| title | Structural and diffusion property alterations in unaffected siblings of patients with obsessive-compulsive disorder |
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