Regulation of ethanol-related behavior and ethanol metabolism by the Corazonin neurons and Corazonin receptor in Drosophila melanogaster

Impaired ethanol metabolism can lead to various alcohol-related health problems. Key enzymes in ethanol metabolism are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH); however, neuroendocrine pathways that regulate the activities of these enzymes are largely unexplored. Here we identif...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e87062-e87062
Hauptverfasser:	Sha, Kai, Choi, Seung-Hoon, Im, Jeongdae, Lee, Gyunghee G, Loeffler, Frank, Park, Jae H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde Acetaldehyde - metabolism Adenosine triphosphatase Alcohol Alcohol dehydrogenase Alcohol Dehydrogenase - genetics Alcohol Dehydrogenase - metabolism Alcoholic beverages Aldehyde dehydrogenase Aldehyde Dehydrogenase - metabolism Alleles Animals Apoptosis Behavior Biochemistry Biology Cancer Corazonin protein Cyclic AMP Cyclic AMP response element-binding protein Cyclic AMP-Dependent Protein Kinases - metabolism Dehydrogenase Dehydrogenases Detoxification Drosophila Drosophila melanogaster Drosophila melanogaster - drug effects Drosophila melanogaster - enzymology Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Energy law Enzymes Ethanol Ethanol - metabolism Ethanol - pharmacology Flies Gene expression Gene regulation Genes, Reporter Genetic engineering Health problems Inhibition Insects Male Medicine Metabolism Molecular biology Mutants Mutation - genetics Neuroendocrine system Neurons Neurons - drug effects Neurons - metabolism Neuropeptides Neuropeptides - metabolism Phenotype Physiological aspects Physiology Polymerase chain reaction Protein binding Protein kinase A Proteins Receptors, Neuropeptide - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Signaling Studies Transcription Transcription (Genetics) Transcription, Genetic
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