Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition

Overexpression of Oct4, an important transcription factor of embryonic stem cells (ESC), has been reported in several cancers. The aim of this study was to determine the emerging role of Oct4 in oral squamous cell carcinoma (OSCC) both in vitro and in vivo. Tumourigenic activity and molecular mechan...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e87207
Hauptverfasser:	Tsai, Lo-Lin, Hu, Fang-Wei, Lee, Shiuan-Shinn, Yu, Chuan-Hang, Yu, Cheng-Chia, Chang, Yu-Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Cancer metastasis Carcinogenesis - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - physiopathology Cell growth Cell Line, Tumor Cell proliferation Cell survival Dentistry DNA Primers - genetics Embryo cells Embryonic stem cells Epithelial cells Epithelial-Mesenchymal Transition - physiology Genetic Vectors - genetics Head & neck cancer Health aspects Hospitals Humans In vitro methods and tests In vivo methods and tests Invasiveness Lymphatic system Medical prognosis Medicine Mesenchyme Metastases Metastasis Mice Mice, Nude Molecular modelling Mouth Neoplasms - metabolism Mouth Neoplasms - physiopathology Oct-4 protein Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Oral cancer Oral carcinoma Oral squamous cell carcinoma Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Silence Squamous cell carcinoma Stem cells Tetrazolium Salts Thiazoles Transformation Tumorigenesis Xenografts Xenotransplantation
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