Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials

We explored the theorized upregulation of platelet-activating factor (PAF)- mediated biologic responses following lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibition using human platelet aggregation studies in an in vitro experiment and in 2 clinical trials. Full platelet aggregation concen...

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Veröffentlicht in:	PloS one 2014, Vol.9 (1), p.e83094
Hauptverfasser:	Shaddinger, Bonnie C, Xu, Yanmei, Roger, James H, Macphee, Colin H, Handel, Malcolm, Baidoo, Charlotte A, Magee, Mindy, Lepore, John J, Sprecher, Dennis L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Adult Agglomeration Analysis of Variance Anaphylaxis Asthma Biology Biometrics Blood & organ donations Blood plasma Blood platelets Cardiovascular disease Clinical trials Collagen (type I) Confidence intervals Cross-Over Studies Dose-Response Relationship, Drug Drug dosages Heart attacks Heart failure Humans Inhibition Lipoproteins Lipoproteins - metabolism Male Medical research Medicine Metabolism Models, Biological New South Wales Phospholipase Phospholipase A2 Phospholipase A2 Inhibitors - metabolism Phospholipase A2 Inhibitors - pharmacology Platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation - physiology Platelet-activating factor Quinolones - pharmacology Randomization Rodents Signal transduction
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