GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure

Oxidative stress, caused by the over production of reactive oxygen species (ROS), has been shown to contribute to cell damage associated with neurotrauma and neurodegenerative diseases. ROS mediates cell damage either through direct oxidation of lipids, proteins and DNA or by acting as signaling mol...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e86951
Hauptverfasser:	Suyama, Kaori, Watanabe, Masahiko, Sakabe, Kou, Otomo, Asako, Okada, Yoshinori, Terayama, Hayato, Imai, Takeshi, Mochida, Joji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants (Nutrients) Apoptosis Biology Bone surgery Brain tumors Cell Line, Tumor Cell Survival Cellular biology Cytotoxicity Damage Deoxyribonucleic acid DNA Endoplasmic reticulum Gene Expression Genes, Reporter Glial cells Glioma cells Glutathione Glutathione - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hydrogen Hydrogen peroxide Hydrogen Peroxide - pharmacology Kinases Lipid Peroxidation Lipids Medicine NAD NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism NADPH quinone oxidoreductase Nervous system diseases Neurodegenerative diseases Neuroglia - cytology Neuroglia - drug effects Neuroglia - metabolism Neurological diseases Orthopedics Oxidation Oxidative stress Oxidoreductase Oxygen Peroxidation Polyclonal antibodies Protein folding Proteins Quinone oxidoreductase Quinones Rats Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Science Signal Transduction Signaling Spinal cord injuries Studies Trauma
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