A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma

Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new anti-cancer candidates with improved immunological properties. Hemocyanins prom...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e87240-e87240
Hauptverfasser:	Arancibia, Sergio, Espinoza, Cecilia, Salazar, Fabián, Del Campo, Miguel, Tampe, Ricardo, Zhong, Ta-Ying, De Ioannes, Pablo, Moltedo, Bruno, Ferreira, Jorge, Lavelle, Ed C, Manubens, Augusto, De Ioannes, Alfredo E, Becker, María Inés
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anticancer properties Antigens Antineoplastic Agents - pharmacology Antitumor agents Biodiversity Biology Bladder cancer Cancer Cancer immunotherapy Carbohydrates Care and treatment CD4 antigen Cell Line, Tumor Cell survival Chromatography, High Pressure Liquid Cytokines Dendritic cells Electrophoresis, Polyacrylamide Gel Fissurella Gastropoda - chemistry Glycoproteins Health aspects Hemocyanins Hemocyanins - isolation & purification Hemocyanins - pharmacology Hemocyanins - ultrastructure Immune response Immune response (humoral) Immune system Immunity, Innate - drug effects Immunization Immunogenicity Immunologic Factors - pharmacology Immunology Immunomodulation Immunotherapy Inflammation Innate immunity Interferon Interleukin 12 Interleukin 23 Interleukin 6 Isoforms Kaplan-Meier Estimate Laboratory animals Lectins Lymphocytes Lymphocytes T Melanoma Melanoma - drug therapy Melanoma - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Microscopy, Electron, Transmission Mollusks Oligosaccharides Oncology, Experimental Oxygen Proteins R&D Research & development Rosaniline Dyes Shellfish Side effects Tumor necrosis factor Tumors Vaccines γ-Interferon
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