Crystal structure of the lamprey variable lymphocyte receptor C reveals an unusual feature in its N-terminal capping module

Jawless vertebrates represented by lampreys and hagfish use variable lymphocyte receptors (VLRs) as antigen receptors to mount adaptive immune responses. VLRs generate diversity that is comparable to immunoglobulins and T-cell receptors by a gene conversion-like mechanism, which is mediated by cytos...

Ausführliche Beschreibung