Over-expression of TRESK K(+) channels reduces the excitability of trigeminal ganglion nociceptors

TWIK-related spinal cord K(+) (TRESK) channel is abundantly expressed in trigeminal ganglion (TG) and dorsal root ganglion neurons and is one of the major background K(+) channels in primary afferent neurons. Mutations in TRESK channels are associated with familial and sporadic migraine. In rats, bo...

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Veröffentlicht in:	PloS one 2014, Vol.9 (1), p.e87029-e87029
Hauptverfasser:	Guo, Zhaohua, Cao, Yu-Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials Analgesics Anesthesiology Animals Biology Capsaicin Capsaicin - pharmacology Cells, Cultured Channel gating Channels Chronic pain Crystal structure Dorsal root ganglia Electrophysiology Excitability Excitation Firing pattern Gene expression Headache HEK293 Cells Heterogeneity Humans Image Processing, Computer-Assisted Lamotrigine Male Medicine Mice Migraine mRNA Mutation Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Nociceptors Overexpression Pain Pain perception Patch-Clamp Techniques Plasmids Potassium Potassium - metabolism Potassium Channels - metabolism Potassium currents Proteins Rats Reduction Rodents Sensory neurons Sensory System Agents - pharmacology Spinal cord Studies Transfection Trigeminal ganglion Trigeminal Ganglion - cytology Trigeminal Ganglion - drug effects Trigeminal Ganglion - metabolism
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