From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract

Birch bark has a long lasting history as a traditional medicinal remedy to accelerate wound healing. Recently, the efficacy of birch bark preparations has also been proven clinically. As active principle pentacyclic triterpenes are generally accepted. Here, we report a comprehensive study on the und...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e86147
Hauptverfasser:	Ebeling, Sandra, Naumann, Katrin, Pollok, Simone, Wardecki, Tina, Vidal-Y-Sy, Sabine, Nascimento, Juliana M, Boerries, Melanie, Schmidt, Gudula, Brandner, Johanna M, Merfort, Irmgard
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Actin Actins - metabolism Animal models Animals Apoptosis Bark Betula - chemistry Biology Biotechnology Cancer Cell adhesion & migration Cell Movement - drug effects Cell Proliferation Chemistry Chemokines Consortia COX-2 inhibitors Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Cytokines - genetics Cytokines - metabolism Cytoskeleton Dermatology Diabetes Disease Models, Animal Effectiveness ELAV Proteins - metabolism Filopodia Gene Expression Regulation - drug effects Herbal medicine Humans HuR protein Inflammation Inflammation Mediators - metabolism Interleukin 6 Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Lamellipodia MAP kinase Medical research Medicinal plants Medicine Migration Molecular modelling mRNA Muscle proteins NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Pharmaceutical industry Pharmaceuticals Plant Bark - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry rho GTP-Binding Proteins - metabolism RNA RNA Stability - drug effects RNA, Messenger - genetics Saponins Signal transduction Skin - drug effects Skin - metabolism STAT3 Transcription Factor - metabolism Swine Terpenes Triterpenes Triterpenes - pharmacology Vegetable oils Wound care Wound healing Wound Healing - drug effects
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