Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells

Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e86787
Hauptverfasser:	Wong, Carmen P, Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M, Houseman, E Andres, Williams, David E, Dashwood, Roderick H, Ho, Emily
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Analysis Analysis of Variance Androgens Anticarcinogenic Agents - pharmacology Apoptosis Biology Breast cancer Cancer Cancer cells Cancer genetics Cancer prevention Cancer treatment Carcinogenesis Carcinogens Care and treatment Cell cycle Cells, Cultured Chemistry Chemokines Chemopreventive agents Chromatin Immunoprecipitation Deoxyribonucleic acid Development and progression DNA DNA methylation DNA Methylation - drug effects DNA Methylation - genetics DNA methyltransferase DNA Primers - genetics Epigenetic inheritance Epigenetics Epithelial cells Epithelial Cells - metabolism Gastric cancer Gene expression Gene silencing Genes Genetic aspects Genetic engineering Genomes Genomics Health sciences Humans Immunomodulation Immunoprecipitation Indoles - pharmacology Isothiocyanates - pharmacology Male Medicine Methylation Modulators Phytochemicals Population Promoter Regions, Genetic - genetics Prostate - cytology Prostate cancer Prostatic Neoplasms - metabolism Real-Time Polymerase Chain Reaction Stomach cancer Sulforaphane Toxicology Tumor suppressor genes
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