Gram-stain plus MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry) for a rapid diagnosis of urinary tract infection

Microbiological confirmation of a urinary tract infection (UTI) takes 24-48 h. In the meantime, patients are usually given empirical antibiotics, sometimes inappropriately. We assessed the feasibility of sequentially performing a Gram stain and MALDI-TOF MS mass spectrometry (MS) on urine samples to...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e86915-e86915
Hauptverfasser:	Burillo, Almudena, Rodríguez-Sánchez, Belén, Ramiro, Ana, Cercenado, Emilia, Rodríguez-Créixems, Marta, Bouza, Emilio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adequacy Algorithms Antibiotics Bacteria Computer Science Culture Desorption Diagnosis Diagnostic systems Feasibility studies Gentian Violet Gram stain Health aspects Humans Infections Ionization Ions Laboratories Lasers Likelihood Functions Likelihood ratio Mass spectrometry Mass spectroscopy Medical diagnosis Medicine Patients Phenazines Predictive Value of Tests Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectroscopy Stains Urinary tract Urinary tract infections Urinary Tract Infections - diagnosis Urinary Tract Infections - microbiology Urine Urine - microbiology
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