Adrenergic β2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro

Vagal nerve efferent activation has been shown to ameliorate the course of many inflammatory disease states. This neuro-modulatory effect has been suggested to rest on acetylcholine receptor (AChR) activation on tissue macrophages or dendritic cells (DCs). In more recent studies, vagal anti-inflamma...

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Veröffentlicht in:	PloS one 2014, Vol.9 (1), p.e85086
Hauptverfasser:	Nijhuis, Laurens E, Olivier, Brenda J, Dhawan, Shobit, Hilbers, Francisca W, Boon, Louis, Wolkers, Monika C, Samsom, Janneke N, de Jonge, Wouter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Adrenergic beta-Agonists - pharmacology Adrenergic receptors Albuterol - pharmacology Animals Anti-inflammatory agents Antigens Biology Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Brain research Cell activation Cells, Cultured Cloning Cytokines Cytokines - metabolism Dendritic cells Dendritic Cells - drug effects Dendritic Cells - metabolism Dextrans - pharmacokinetics Disease Endocytosis Endocytosis - drug effects Epinephrine - pharmacology Experiments Female Flow Cytometry Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - pharmacokinetics Forkhead Transcription Factors - metabolism Foxp3 protein Growth factors Homeostasis Immune system Immunology Inflammation Inflammation Mediators - metabolism Interleukin 1 Interleukin 10 Interleukin 12 Interleukin 23 Interleukin 6 Interleukin-10 - metabolism Interleukin-12 - metabolism Interleukin-23 - metabolism Interleukin-6 - metabolism Laboratories Liver Lymphocytes Lymphocytes T Macrophages Medicine Mice Mice, Inbred C57BL Nervous system Neuropeptides Receptor mechanisms Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism Retinoic acid Reverse Transcriptase Polymerase Chain Reaction Rodents Spleen T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism Vagus nerve
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