Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines

The neuronal actin-binding protein drebrin A forms a stable structure with F-actin in dendritic spines. NMDA receptor activation causes an exodus of F-actin bound by drebrin A (DA-actin) from dendritic spines, suggesting a pivotal role for DA-actin exodus in synaptic plasticity. We quantitatively as...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e85367
Hauptverfasser:	Mizui, Toshiyuki, Sekino, Yuko, Yamazaki, Hiroyuki, Ishizuka, Yuta, Takahashi, Hideto, Kojima, Nobuhiko, Kojima, Masami, Shirao, Tomoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Activation Adenosine triphosphatase Adenosine Triphosphatases - metabolism Animals Bicuculline - pharmacology Biology Calcium - metabolism Calcium influx Cells, Cultured Dendritic plasticity Dendritic spines Dendritic Spines - drug effects Dendritic Spines - metabolism Dendritic Spines - physiology Dendritic structure Dopamine receptors Enlargement Female GABA-A Receptor Antagonists - pharmacology Gene expression Glutamic Acid - pharmacology Glutamic acid receptors (ionotropic) Glycine - pharmacology Hippocampus Hippocampus - cytology Localization Long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Medical research Medicine Microscopy, Fluorescence Muscle proteins Myosin Myosin Type II - metabolism Myosin-light-chain kinase N-Methyl-D-aspartic acid receptors Neurobiology Neurons Neurons - cytology Neurons - metabolism Neuropeptides - metabolism Neurosciences Phosphorylation Polymerization Potentiation Pregnancy Protein Binding Rats Rats, Wistar Receptor mechanisms Receptors Receptors, N-Methyl-D-Aspartate - metabolism Rho-associated kinase Rodents Science Spine Synaptic plasticity Tetrodotoxin - pharmacology Time-Lapse Imaging University graduates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!