Lesions of cholinergic pedunculopontine tegmental nucleus neurons fail to affect cocaine or heroin self-administration or conditioned place preference in rats

Cholinergic input to the ventral tegmental area (VTA) is known to contribute to reward. Although it is known that the pedunculopontine tegmental nucleus (PPTg) provides an important source of excitatory input to the dopamine system, the specific role of PPTg cholinergic input to the VTA in cocaine r...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e84412
Hauptverfasser:	Steidl, Stephan, Wang, Huiling, Wise, Roy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animal behavior Animals Biology Brain research Cell Death - drug effects Cholinergic Agents - pharmacology Cholinergic Neurons - drug effects Cholinergic Neurons - metabolism Cholinergic Neurons - pathology Cocaine Cocaine - administration & dosage Conditioning Conditioning (Psychology) Diphtheria Diphtheria toxin Diphtheria Toxin - administration & dosage Diphtheria Toxin - toxicity Dopamine Dopamine - metabolism Drug abuse Drug self-administration GABA Glutamatergic transmission Heroin Heroin - administration & dosage Lesions Male Medicine Neurons Neurosciences Neurotoxins - administration & dosage Neurotoxins - toxicity Nuclei Pedunculopontine tegmental nucleus Pedunculopontine Tegmental Nucleus - drug effects Pedunculopontine Tegmental Nucleus - metabolism Pedunculopontine Tegmental Nucleus - pathology Place preference conditioning Preferences Rats Rats, Long-Evans Receptors Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - toxicity Reinforcement Rodents Self Administration Substance-Related Disorders - metabolism Substance-Related Disorders - pathology Tegmental nucleus Urotensins - administration & dosage Ventral tegmentum
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!