Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model

Epilepsy is a disorder characterized by excessive synchronized neural activity. The hippocampus and surrounding temporal lobe structures appear particularly sensitive to epileptiform activity. Somatostatin (SST)-positive interneurons within the hilar region have been suggested to gate hippocampal ac...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e86250-e86250
Hauptverfasser:	Grosser, Sabine, Queenan, Bridget N, Lalchandani, Rupa R, Vicini, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Action Potentials - drug effects Animals Biology Brain Calcium Calcium - metabolism Calcium imaging Coding Electrodes Electrophysiological recording Epilepsy Epilepsy, Temporal Lobe - metabolism GABA gamma-Aminobutyric Acid - metabolism Genetic code Glutamatergic transmission Hippocampus Interdisciplinary aspects Interneurons Interneurons - drug effects Interneurons - metabolism Laboratory animals Medicine Mice Neurons Neurosciences Pharmacology Physiology Rodents Seizures Somatostatin Somatostatin - metabolism Temporal lobe γ-Aminobutyric acid
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