Engineering the Saccharomyces cerevisiae β-oxidation pathway to increase medium chain fatty acid production as potential biofuel

Fatty acid-derived biofuels and biochemicals can be produced in microbes using β-oxidation pathway engineering. In this study, the β-oxidation pathway of Saccharomyces cerevisiae was engineered to accumulate a higher ratio of medium chain fatty acids (MCFAs) when cells were grown on fatty acid-rich...

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Veröffentlicht in:	PloS one 2014, Vol.9 (1), p.e84853-e84853
Hauptverfasser:	Chen, Liwei, Zhang, Jianhua, Chen, Wei Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Acid production Acyl Coenzyme A - metabolism Acyl-CoA oxidase Acyl-CoA Oxidase - deficiency Acyl-CoA Oxidase - genetics Biodiesel fuels Biofuels Biology Carnitine Carnitine Acyltransferases - genetics Carnitine Acyltransferases - metabolism Carnitine O-octanoyltransferase Cell culture Chains Clonal deletion Cytoplasm - enzymology Defects Engineering Fatty acids Fatty Acids - biosynthesis Isoenzymes - genetics Isoenzymes - metabolism Lipids Metabolic Engineering Mus musculus Oxidase Oxidation Oxidation-Reduction Peroxisomes Peroxisomes - enzymology Raw materials Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Transgenes Yarrowia - chemistry Yarrowia - enzymology Yarrowia lipolytica Yeast
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