Tractography of the brainstem in major depressive disorder using diffusion tensor imaging
The brainstem is the main region that innervates neurotransmitter release to the Hypothalamic-Pituitary Adrenal (HPA) axis and fronto-limbic circuits, two key brain circuits found to be dysfunctional in Major Depressive Disorder (MDD). However, the brainstem's role in MDD has only been evaluate...
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| creator | Song, Yun Ju C Korgaonkar, Mayuresh S Armstrong, Lucy V Eagles, Sarah Williams, Leanne M Grieve, Stuart M |
| description | The brainstem is the main region that innervates neurotransmitter release to the Hypothalamic-Pituitary Adrenal (HPA) axis and fronto-limbic circuits, two key brain circuits found to be dysfunctional in Major Depressive Disorder (MDD). However, the brainstem's role in MDD has only been evaluated in limited reports. Using Diffusion Tensor Imaging (DTI), we investigated whether major brainstem white matter tracts that relate to these two circuits differ in MDD patients compared to healthy controls.
MDD patients (n = 95) and age- and gender-matched controls (n = 34) were assessed using probabilistic tractography of DTI to delineate three distinct brainstem tracts: the nigrostriatal tract (connecting brainstem to striatum), solitary tract (connecting brainstem to amygdala) and corticospinal tract (connecting brainstem to precentral cortex). Fractional anisotropy (FA) was used to measure the white matter integrity of these tracts, and measures were compared between MDD and control participants.
MDD participants were characterized by a significant and specific decrease in white matter integrity of the right solitary tract (p |
| doi_str_mv | 10.1371/journal.pone.0084825 |
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MDD patients (n = 95) and age- and gender-matched controls (n = 34) were assessed using probabilistic tractography of DTI to delineate three distinct brainstem tracts: the nigrostriatal tract (connecting brainstem to striatum), solitary tract (connecting brainstem to amygdala) and corticospinal tract (connecting brainstem to precentral cortex). Fractional anisotropy (FA) was used to measure the white matter integrity of these tracts, and measures were compared between MDD and control participants.
MDD participants were characterized by a significant and specific decrease in white matter integrity of the right solitary tract (p<0.009 using independent t-test), which is a "bottom up" afferent pathway that connects the brainstem to the amygdala. This decrease was not related to symptom severity.
The results provide new evidence to suggest that structural connectivity between the brainstem and the amygdala is altered in MDD. These results are interesting in light of predominant theories regarding amygdala-mediated emotional reactivity observed in functional imaging studies of MDD. The characterization of altered white matter integrity in the solitary tract in MDD supports the possibility of dysfunctional brainstem-amygdala connectivity impacting vulnerable circuits in MDD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0084825</identifier><identifier>PMID: 24465436</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Amygdala ; Amygdala - pathology ; Amygdala - physiopathology ; Anisotropy ; Biology ; Brain ; Brain Mapping - methods ; Brain stem ; Brain Stem - pathology ; Brain Stem - physiopathology ; Case-Control Studies ; Circuits ; Comparative analysis ; Connectivity ; Control methods ; Depressive Disorder, Major - pathology ; Depressive Disorder, Major - physiopathology ; Diffusion ; Diffusion Tensor Imaging ; Discipline ; Female ; Humans ; Hypothalamic-pituitary-adrenal axis ; Hypothalamus ; Imaging ; Integrity ; Magnetic resonance imaging ; Major depressive disorder ; Male ; Medical schools ; Medicine ; Mental depression ; Middle Aged ; Neostriatum ; Neural networks ; Neurobiology ; Neuroimaging ; Neurotransmitter release ; NMR ; Nuclear magnetic resonance ; Patients ; Pituitary ; Psychiatry ; Pyramidal tracts ; Review boards ; Rodents ; Schizophrenia ; Sensory neurons ; Solitary tract nucleus ; Studies ; Substantia alba</subject><ispartof>PloS one, 2014-01, Vol.9 (1), p.e84825-e84825</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Song et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Song et al 2014 Song et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-35fd7c5a7f318199b673c10704c3df5223abe2b1d3ee09f6868311ca95bfae043</citedby><cites>FETCH-LOGICAL-c758t-35fd7c5a7f318199b673c10704c3df5223abe2b1d3ee09f6868311ca95bfae043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897382/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897382/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24465436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Yun Ju C</creatorcontrib><creatorcontrib>Korgaonkar, Mayuresh S</creatorcontrib><creatorcontrib>Armstrong, Lucy V</creatorcontrib><creatorcontrib>Eagles, Sarah</creatorcontrib><creatorcontrib>Williams, Leanne M</creatorcontrib><creatorcontrib>Grieve, Stuart M</creatorcontrib><title>Tractography of the brainstem in major depressive disorder using diffusion tensor imaging</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The brainstem is the main region that innervates neurotransmitter release to the Hypothalamic-Pituitary Adrenal (HPA) axis and fronto-limbic circuits, two key brain circuits found to be dysfunctional in Major Depressive Disorder (MDD). However, the brainstem's role in MDD has only been evaluated in limited reports. Using Diffusion Tensor Imaging (DTI), we investigated whether major brainstem white matter tracts that relate to these two circuits differ in MDD patients compared to healthy controls.
MDD patients (n = 95) and age- and gender-matched controls (n = 34) were assessed using probabilistic tractography of DTI to delineate three distinct brainstem tracts: the nigrostriatal tract (connecting brainstem to striatum), solitary tract (connecting brainstem to amygdala) and corticospinal tract (connecting brainstem to precentral cortex). Fractional anisotropy (FA) was used to measure the white matter integrity of these tracts, and measures were compared between MDD and control participants.
MDD participants were characterized by a significant and specific decrease in white matter integrity of the right solitary tract (p<0.009 using independent t-test), which is a "bottom up" afferent pathway that connects the brainstem to the amygdala. This decrease was not related to symptom severity.
The results provide new evidence to suggest that structural connectivity between the brainstem and the amygdala is altered in MDD. These results are interesting in light of predominant theories regarding amygdala-mediated emotional reactivity observed in functional imaging studies of MDD. The characterization of altered white matter integrity in the solitary tract in MDD supports the possibility of dysfunctional brainstem-amygdala connectivity impacting vulnerable circuits in MDD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Amygdala</subject><subject>Amygdala - pathology</subject><subject>Amygdala - physiopathology</subject><subject>Anisotropy</subject><subject>Biology</subject><subject>Brain</subject><subject>Brain Mapping - methods</subject><subject>Brain stem</subject><subject>Brain Stem - pathology</subject><subject>Brain Stem - physiopathology</subject><subject>Case-Control Studies</subject><subject>Circuits</subject><subject>Comparative analysis</subject><subject>Connectivity</subject><subject>Control methods</subject><subject>Depressive Disorder, Major - pathology</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Diffusion</subject><subject>Diffusion Tensor Imaging</subject><subject>Discipline</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothalamic-pituitary-adrenal axis</subject><subject>Hypothalamus</subject><subject>Imaging</subject><subject>Integrity</subject><subject>Magnetic resonance imaging</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Neostriatum</subject><subject>Neural networks</subject><subject>Neurobiology</subject><subject>Neuroimaging</subject><subject>Neurotransmitter release</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Pituitary</subject><subject>Psychiatry</subject><subject>Pyramidal tracts</subject><subject>Review boards</subject><subject>Rodents</subject><subject>Schizophrenia</subject><subject>Sensory neurons</subject><subject>Solitary tract nucleus</subject><subject>Studies</subject><subject>Substantia alba</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1trFDEUxwdRbK1-A9EBQfRh19xmkrwIpXhZKBS0Cj6FTOZkNsvsZE0yxX57s91p6UgfJA-5nN_5n-TknKJ4idESU44_bPwYBt0vd36AJUKCCVI9Ko6xpGRRE0Qf31sfFc9i3CBUUVHXT4sjwlhdMVofF78ugzbJd0Hv1telt2VaQ9kE7YaYYFu6odzqjQ9lC7sAMborKFsXfWghlGN0Q5e31uaVH8oEQ7aUbqu7bHhePLG6j_Bimk-KH58_XZ59XZxffFmdnZ4vDK9EWtDKttxUmluKBZayqTk1GHHEDG1tRQjVDZAGtxQASVuLWlCMjZZVYzUgRk-K1wfdXe-jmrISFWYSSUm4xJlYHYjW643ahXzBcK28durmwIdO6ZCc6UERzjhoWgluc0IRF9BQ0AQ3xtSWyDZrfZyijc0WWgNDCrqfic4tg1urzl8pKiSngmSBd5NA8L9HiEltXTTQ93oAP97cm9RC4nqPvvkHffh1E9Xp_AA3WJ_jmr2oOmVciKpiTGZq-QCVRwtbZ3IJWZfPZw7vZw6ZSfAndXqMUa2-f_t_9uLnnH17j12D7tM6-n5MuYLiHGQH0AQfYwB7l2SM1L4DbrOh9h2gpg7Ibq_uf9Cd023J079uuQGf</recordid><startdate>20140121</startdate><enddate>20140121</enddate><creator>Song, Yun Ju 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of the brainstem in major depressive disorder using diffusion tensor imaging</title><author>Song, Yun Ju C ; Korgaonkar, Mayuresh S ; Armstrong, Lucy V ; Eagles, Sarah ; Williams, Leanne M ; Grieve, Stuart M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-35fd7c5a7f318199b673c10704c3df5223abe2b1d3ee09f6868311ca95bfae043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Amygdala</topic><topic>Amygdala - pathology</topic><topic>Amygdala - physiopathology</topic><topic>Anisotropy</topic><topic>Biology</topic><topic>Brain</topic><topic>Brain Mapping - methods</topic><topic>Brain stem</topic><topic>Brain Stem - pathology</topic><topic>Brain Stem - physiopathology</topic><topic>Case-Control Studies</topic><topic>Circuits</topic><topic>Comparative analysis</topic><topic>Connectivity</topic><topic>Control methods</topic><topic>Depressive Disorder, Major - pathology</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Diffusion</topic><topic>Diffusion Tensor Imaging</topic><topic>Discipline</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothalamic-pituitary-adrenal axis</topic><topic>Hypothalamus</topic><topic>Imaging</topic><topic>Integrity</topic><topic>Magnetic resonance imaging</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Neostriatum</topic><topic>Neural networks</topic><topic>Neurobiology</topic><topic>Neuroimaging</topic><topic>Neurotransmitter release</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Pituitary</topic><topic>Psychiatry</topic><topic>Pyramidal tracts</topic><topic>Review boards</topic><topic>Rodents</topic><topic>Schizophrenia</topic><topic>Sensory 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One</addtitle><date>2014-01-21</date><risdate>2014</risdate><volume>9</volume><issue>1</issue><spage>e84825</spage><epage>e84825</epage><pages>e84825-e84825</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The brainstem is the main region that innervates neurotransmitter release to the Hypothalamic-Pituitary Adrenal (HPA) axis and fronto-limbic circuits, two key brain circuits found to be dysfunctional in Major Depressive Disorder (MDD). However, the brainstem's role in MDD has only been evaluated in limited reports. Using Diffusion Tensor Imaging (DTI), we investigated whether major brainstem white matter tracts that relate to these two circuits differ in MDD patients compared to healthy controls.
MDD patients (n = 95) and age- and gender-matched controls (n = 34) were assessed using probabilistic tractography of DTI to delineate three distinct brainstem tracts: the nigrostriatal tract (connecting brainstem to striatum), solitary tract (connecting brainstem to amygdala) and corticospinal tract (connecting brainstem to precentral cortex). Fractional anisotropy (FA) was used to measure the white matter integrity of these tracts, and measures were compared between MDD and control participants.
MDD participants were characterized by a significant and specific decrease in white matter integrity of the right solitary tract (p<0.009 using independent t-test), which is a "bottom up" afferent pathway that connects the brainstem to the amygdala. This decrease was not related to symptom severity.
The results provide new evidence to suggest that structural connectivity between the brainstem and the amygdala is altered in MDD. These results are interesting in light of predominant theories regarding amygdala-mediated emotional reactivity observed in functional imaging studies of MDD. The characterization of altered white matter integrity in the solitary tract in MDD supports the possibility of dysfunctional brainstem-amygdala connectivity impacting vulnerable circuits in MDD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24465436</pmid><doi>10.1371/journal.pone.0084825</doi><tpages>e84825</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-01, Vol.9 (1), p.e84825-e84825 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Aged Amygdala Amygdala - pathology Amygdala - physiopathology Anisotropy Biology Brain Brain Mapping - methods Brain stem Brain Stem - pathology Brain Stem - physiopathology Case-Control Studies Circuits Comparative analysis Connectivity Control methods Depressive Disorder, Major - pathology Depressive Disorder, Major - physiopathology Diffusion Diffusion Tensor Imaging Discipline Female Humans Hypothalamic-pituitary-adrenal axis Hypothalamus Imaging Integrity Magnetic resonance imaging Major depressive disorder Male Medical schools Medicine Mental depression Middle Aged Neostriatum Neural networks Neurobiology Neuroimaging Neurotransmitter release NMR Nuclear magnetic resonance Patients Pituitary Psychiatry Pyramidal tracts Review boards Rodents Schizophrenia Sensory neurons Solitary tract nucleus Studies Substantia alba |
| title | Tractography of the brainstem in major depressive disorder using diffusion tensor imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A27%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tractography%20of%20the%20brainstem%20in%20major%20depressive%20disorder%20using%20diffusion%20tensor%20imaging&rft.jtitle=PloS%20one&rft.au=Song,%20Yun%20Ju%20C&rft.date=2014-01-21&rft.volume=9&rft.issue=1&rft.spage=e84825&rft.epage=e84825&rft.pages=e84825-e84825&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0084825&rft_dat=%3Cgale_plos_%3EA478855449%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1490992791&rft_id=info:pmid/24465436&rft_galeid=A478855449&rft_doaj_id=oai_doaj_org_article_2747ea3587f848078eb3ea21bcc6f29d&rfr_iscdi=true |