Aberrant activation of the WNT/β-catenin signaling pathway in lupus nephritis

The canonical WNT pathway has been implicated as playing important roles in the pathogenesis of a variety of kidney diseases. Recently, WNT pathway activity was reported to be elevated in the renal tissue of a lupus mouse model. This study aimed to evaluate the potential role of the WNT pathway in t...

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Veröffentlicht in:	PloS one 2014, Vol.9 (1), p.e84852-e84852
Hauptverfasser:	Wang, Xiao-Dong, Huang, Xin-Fang, Yan, Qing-Ran, Bao, Chun-de
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adult Anti-DNA antibodies Antibodies, Antinuclear - blood Antigens Arthritis Autoimmune diseases Axin Protein - genetics Axin Protein - metabolism beta Catenin - genetics beta Catenin - metabolism Biology Biopsy Cancer Case-Control Studies Classification Complement C3 - metabolism Correlation Creatinine Creatinine - blood Disease Dkk1 protein Enzyme-linked immunosorbent assay Female Fibrosis Gangrene Gene Expression Hospitals Humans Immunohistochemistry Intercellular Signaling Peptides and Proteins - blood Intercellular Signaling Peptides and Proteins - genetics Kidney - metabolism Kidney - pathology Kidney diseases Kidney Function Tests Kidney transplantation Kidneys Kinases Lupus Lupus nephritis Lupus Nephritis - genetics Lupus Nephritis - metabolism Lupus Nephritis - pathology Male Medicine Middle Aged Nephritis Pathogenesis Patients Plasma levels Polymerase chain reaction Proteins Rheumatology Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Signaling Tissues Western blotting Wnt protein Wnt Signaling Pathway - genetics β-Catenin
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