Critical amino acids within the human immunodeficiency virus type 1 envelope glycoprotein V4 N- and C-terminals contribute to virus entry

The importance of the fourth variable (V4) region of the human immunodeficiency virus 1 (HIV-1) envelope glycoprotein (Env) in virus infection has not been well clarified, though the polymorphism of this region has been found to be associated with disease progression to acquired immunodeficiency syn...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e86083
Hauptverfasser:	Li, Yan, Yang, Dan, Wang, Jia-Ye, Yao, Yuan, Zhang, Wei-Zhe, Wang, Lu-Jing, Cheng, De-Chun, Yang, Feng-Kun, Zhang, Feng-Min, Zhuang, Min, Ling, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Amino Acid Sequence Amino Acid Substitution Amino acids Amino Acids - metabolism Biochemistry Biology CCR5 protein Clinical trials Computational Biology Conserved Sequence CXCR4 protein Education Electrostatic properties Evolution, Molecular Glycoprotein gp120 Glycoprotein gp160 Glycoproteins Glycosylation Health aspects HEK293 Cells HIV HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - metabolism HIV-1 - metabolism HIV-1 - pathogenicity HIV-1 - physiology Human immunodeficiency virus Humans Hydrophobicity Infection Infections Infectivity Laboratories Medicine Models, Molecular Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - metabolism Mutation Parasitology Polymorphism Protein Structure, Tertiary Receptors, CCR5 - metabolism Receptors, CXCR4 - metabolism Static Electricity Structure-Activity Relationship Terminals Viral infections Viral Tropism Virus diseases Virus Internalization Viruses
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