Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease

The ability to reconstitute a normal immune system with antiretroviral therapy in the setting of HIV infection remains uncertain. This study aimed to characterize quantitative and qualitative aspects of various T cell subpopulations that do not improve despite effective ART. CD4∶CD8 ratio was evalua...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e85613-e85613
Hauptverfasser:	Emu, Brinda, Moretto, Walter J, Hoh, Rebecca, Krone, Melissa, Martin, Jeffrey N, Nixon, Douglas F, Deeks, Steven G, McCune, Joseph M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Anti-HIV Agents - therapeutic use Antigens, CD - genetics Antigens, CD - immunology Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Biology Care and treatment CCR7 protein CD27 antigen CD28 antigen CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology CD45RA antigen CD8 antigen CD8-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - virology Compartments Control Controllers Cytomegalovirus Disease Progression Female Gene Expression Health aspects Highly active antiretroviral therapy HIV HIV infections HIV Infections - drug therapy HIV Infections - immunology HIV Infections - pathology HIV Infections - virology HIV-1 - drug effects HIV-1 - immunology Human immunodeficiency virus Humans Immune system Infection Interferon Lymphocyte Activation Lymphocytes Lymphocytes T Male Medical treatment Medicine Middle Aged Mortality Prospective Studies Qualitative analysis Subpopulations T cells T-Lymphocyte Subsets - pathology T-Lymphocyte Subsets - virology Viral Load - drug effects
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