Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells

Arachidonate 15-lipoxygenase-1 (ALOX15) oxygenates polyunsaturated fatty acids and bio-membranes, generating multiple lipid signalling mediators involved in inflammation. Several lines of evidence indicate that ALOX15 activation in the respiratory tract contributes to asthma progression. Recent expe...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e85085-e85085
Hauptverfasser:	Han, Hongya, Xu, Dawei, Liu, Cheng, Claesson, Hans-Erik, Björkholm, Magnus, Sjöberg, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Apoptosis Arachidonate 15-lipoxygenase Arachidonate 15-Lipoxygenase - genetics Arachidonate 15-Lipoxygenase - metabolism Asthma Biology Blood & organ donations Cancer Cell Line Cell Line, Tumor Cells, Cultured Chromatin Chromatin Immunoprecipitation Cytokines Demethylation Dendritic cells Enzymes Epigenetics Fatty acids Gene expression Genes Genetic aspects Hematology Histone Demethylases - genetics Histone Demethylases - metabolism Histone H3 Histones - metabolism Hodgkin's disease Hodgkin's lymphoma Hospitals Humans Immunoprecipitation Interleukin Interleukin 4 Interleukin-4 - metabolism Interleukin-4 - pharmacology Interleukins Lipoxygenase Lung carcinoma Lymphoma Lymphomas Lysine Medicine Membranes Monocytes Nuclear Proteins - genetics Nuclear Proteins - metabolism Polyunsaturated fatty acids Promoter Regions, Genetic - genetics Protein Binding - drug effects Proteins Recruitment Respiratory tract Signal transduction Signaling siRNA Telomerase Transcription (Genetics) Transcription activation Unsaturated fatty acids
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