Metformin: a potential therapeutic agent for recurrent colon cancer

Accumulating evidence suggests that metformin, a biguanide class of anti-diabetic drugs, possesses anti-cancer properties. However, most of the studies to evaluate therapeutic efficacy of metformin have been on primary cancer. No information is available whether metformin could be effectively used f...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e84369
Hauptverfasser:	Nangia-Makker, Pratima, Yu, Yingjie, Vasudevan, Anita, Farhana, Lulu, Rajendra, Sindhu G, Levi, Edi, Majumdar, Adhip P N
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Animals Anticancer properties Antidiabetics Apoptosis Beta cells Biology Breast cancer Cancer Cancer research Cell culture Cell cycle Cell death Cell migration Cell Movement - drug effects Cell survival Chemical compounds Chemotherapy Colon Colon cancer Colonic Neoplasms - drug therapy Colorectal cancer Colorectal carcinoma Combinatorial analysis Diabetes Diabetes mellitus Diabetes therapy Disintegration Drug therapy Drugs Female Fluorouracil - therapeutic use Gastrointestinal diseases HCT116 Cells Health aspects HT29 Cells Humans Internal medicine Kinases Medicine Metformin Metformin - therapeutic use Mice Mice, SCID miRNA Neoplasm Recurrence, Local - drug therapy Organoplatinum Compounds - therapeutic use Oxaliplatin Pharmacology Recurrence (Disease) Rodents Signal transduction Signaling Stem cells Tumors Veterans Wnt protein Xenografts β-Catenin
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