Plasma selenium biomarkers in low income black and white americans from the southeastern United States
Biomarkers of selenium are necessary for assessing selenium status in humans, since soil variation hinders estimation of selenium intake from foods. In this study, we measured the concentration of plasma selenium, selenoprotein P (SEPP1), and glutathione peroxidase (GPX3) activity and their interind...
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| description | Biomarkers of selenium are necessary for assessing selenium status in humans, since soil variation hinders estimation of selenium intake from foods. In this study, we measured the concentration of plasma selenium, selenoprotein P (SEPP1), and glutathione peroxidase (GPX3) activity and their interindividual differences in 383 low-income blacks and whites selected from a stratified random sample of adults aged 40-79 years, who were participating in a long-term cohort study in the southeastern United States (US). We assessed the utility of these biomarkers to determine differences in selenium status and their association with demographic, socio-economic, dietary, and other indicators. Dietary selenium intake was assessed using a validated food frequency questionnaire designed for the cohort, matched with region-specific food selenium content, and compared with the US Recommended Dietary Allowances (RDA) set at 55 µg/day. We found that SEPP1, a sensitive biomarker of selenium nutritional status, was significantly lower among blacks than whites (mean 4.4 ± 1.1 vs. 4.7 ± 1.0 mg/L, p = 0.006), with blacks less than half as likely to have highest vs. lowest quartile SEPP1 concentration (Odds Ratio (OR) 0.4, 95% Confidence Interval (CI) 0.2-0.8). The trend in a similar direction was observed for plasma selenium among blacks and whites, (mean 115 ± 15.1 vs. 118 ± 17.7 µg/L, p = 0.08), while GPX3 activity did not differ between blacks and whites (136 ± 33.3 vs. 132 ± 33.5 U/L, p = 0.320). Levels of the three biomarkers were not correlated with estimated dietary selenium intake, except for SEPP1 among 10% of participants with the lowest selenium intake (≤ 57 µg/day). The findings suggest that SEPP1 may be an effective biomarker of selenium status and disease risk in adults and that low selenium status may disproportionately affect black and white cohort participants. |
| doi_str_mv | 10.1371/journal.pone.0084972 |
| format | Article |
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In this study, we measured the concentration of plasma selenium, selenoprotein P (SEPP1), and glutathione peroxidase (GPX3) activity and their interindividual differences in 383 low-income blacks and whites selected from a stratified random sample of adults aged 40-79 years, who were participating in a long-term cohort study in the southeastern United States (US). We assessed the utility of these biomarkers to determine differences in selenium status and their association with demographic, socio-economic, dietary, and other indicators. Dietary selenium intake was assessed using a validated food frequency questionnaire designed for the cohort, matched with region-specific food selenium content, and compared with the US Recommended Dietary Allowances (RDA) set at 55 µg/day. We found that SEPP1, a sensitive biomarker of selenium nutritional status, was significantly lower among blacks than whites (mean 4.4 ± 1.1 vs. 4.7 ± 1.0 mg/L, p = 0.006), with blacks less than half as likely to have highest vs. lowest quartile SEPP1 concentration (Odds Ratio (OR) 0.4, 95% Confidence Interval (CI) 0.2-0.8). The trend in a similar direction was observed for plasma selenium among blacks and whites, (mean 115 ± 15.1 vs. 118 ± 17.7 µg/L, p = 0.08), while GPX3 activity did not differ between blacks and whites (136 ± 33.3 vs. 132 ± 33.5 U/L, p = 0.320). Levels of the three biomarkers were not correlated with estimated dietary selenium intake, except for SEPP1 among 10% of participants with the lowest selenium intake (≤ 57 µg/day). The findings suggest that SEPP1 may be an effective biomarker of selenium status and disease risk in adults and that low selenium status may disproportionately affect black and white cohort participants.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0084972</identifier><identifier>PMID: 24465457</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; African Americans ; Aged ; Alcohol ; Bioindicators ; Biological markers ; Biology ; Biomarkers ; Biomarkers - blood ; Black or African American ; Black People ; Blood & organ donations ; Cancer ; Confidence intervals ; Demographics ; Diet ; Dietary intake ; Family medical history ; Female ; Food ; Food habits ; Food intake ; Gastroenterology ; Glutathione ; Glutathione peroxidase ; Health care ; Health risks ; Hepatology ; Humans ; Income ; Internal medicine ; Low income groups ; Male ; Medicine ; Middle Aged ; Mortality ; Nutrition ; Nutritional status ; Peroxidase ; Plasma ; Prostate ; Public health ; Selenium ; Selenium (Chemical element) ; Selenium - blood ; Southeastern United States ; Urine ; Vitamin E ; White People</subject><ispartof>PloS one, 2014-01, Vol.9 (1), p.e84972</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Hargreaves et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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The findings suggest that SEPP1 may be an effective biomarker of selenium status and disease risk in adults and that low selenium status may disproportionately affect black and white cohort participants.</description><subject>Adult</subject><subject>Adults</subject><subject>African Americans</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Blood & organ donations</subject><subject>Cancer</subject><subject>Confidence intervals</subject><subject>Demographics</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Family medical history</subject><subject>Female</subject><subject>Food</subject><subject>Food habits</subject><subject>Food intake</subject><subject>Gastroenterology</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Health care</subject><subject>Health risks</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Income</subject><subject>Internal medicine</subject><subject>Low income groups</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nutrition</subject><subject>Nutritional status</subject><subject>Peroxidase</subject><subject>Plasma</subject><subject>Prostate</subject><subject>Public health</subject><subject>Selenium</subject><subject>Selenium (Chemical element)</subject><subject>Selenium - 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In this study, we measured the concentration of plasma selenium, selenoprotein P (SEPP1), and glutathione peroxidase (GPX3) activity and their interindividual differences in 383 low-income blacks and whites selected from a stratified random sample of adults aged 40-79 years, who were participating in a long-term cohort study in the southeastern United States (US). We assessed the utility of these biomarkers to determine differences in selenium status and their association with demographic, socio-economic, dietary, and other indicators. Dietary selenium intake was assessed using a validated food frequency questionnaire designed for the cohort, matched with region-specific food selenium content, and compared with the US Recommended Dietary Allowances (RDA) set at 55 µg/day. We found that SEPP1, a sensitive biomarker of selenium nutritional status, was significantly lower among blacks than whites (mean 4.4 ± 1.1 vs. 4.7 ± 1.0 mg/L, p = 0.006), with blacks less than half as likely to have highest vs. lowest quartile SEPP1 concentration (Odds Ratio (OR) 0.4, 95% Confidence Interval (CI) 0.2-0.8). The trend in a similar direction was observed for plasma selenium among blacks and whites, (mean 115 ± 15.1 vs. 118 ± 17.7 µg/L, p = 0.08), while GPX3 activity did not differ between blacks and whites (136 ± 33.3 vs. 132 ± 33.5 U/L, p = 0.320). Levels of the three biomarkers were not correlated with estimated dietary selenium intake, except for SEPP1 among 10% of participants with the lowest selenium intake (≤ 57 µg/day). The findings suggest that SEPP1 may be an effective biomarker of selenium status and disease risk in adults and that low selenium status may disproportionately affect black and white cohort participants.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24465457</pmid><doi>10.1371/journal.pone.0084972</doi><tpages>e84972</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1490679560 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Adults African Americans Aged Alcohol Bioindicators Biological markers Biology Biomarkers Biomarkers - blood Black or African American Black People Blood & organ donations Cancer Confidence intervals Demographics Diet Dietary intake Family medical history Female Food Food habits Food intake Gastroenterology Glutathione Glutathione peroxidase Health care Health risks Hepatology Humans Income Internal medicine Low income groups Male Medicine Middle Aged Mortality Nutrition Nutritional status Peroxidase Plasma Prostate Public health Selenium Selenium (Chemical element) Selenium - blood Southeastern United States Urine Vitamin E White People |
| title | Plasma selenium biomarkers in low income black and white americans from the southeastern United States |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A12%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20selenium%20biomarkers%20in%20low%20income%20black%20and%20white%20americans%20from%20the%20southeastern%20United%20States&rft.jtitle=PloS%20one&rft.au=Hargreaves,%20Margaret%20K&rft.date=2014-01-20&rft.volume=9&rft.issue=1&rft.spage=e84972&rft.pages=e84972-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0084972&rft_dat=%3Cgale_plos_%3EA478859772%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1490679560&rft_id=info:pmid/24465457&rft_galeid=A478859772&rft_doaj_id=oai_doaj_org_article_88e0fb877ae2437d9cc9ff10e9e5795c&rfr_iscdi=true |