Human lactate dehydrogenase a inhibitors: a molecular dynamics investigation

Lactate dehydrogenase A (LDHA) is an important enzyme in fermentative glycolysis, generating most energy for cancer cells that rely on anaerobic respiration even under normal oxygen concentrations. This renders LDHA a promising molecular target for the treatment of various cancers. Several efforts h...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e86365-e86365
Hauptverfasser:	Shi, Yun, Pinto, B Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobic respiration Binding Binding Sites Biology Cancer Chemistry Crystallography Dehydrogenase Dehydrogenases Dynamic tests Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes Fermentation Glycolysis Humans Inhibitors Investigations Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - metabolism Kinetics L-Lactate dehydrogenase L-Lactate Dehydrogenase - antagonists & inhibitors L-Lactate Dehydrogenase - chemistry L-Lactate Dehydrogenase - metabolism Lactate dehydrogenase Lactic acid Ligands Medicine Molecular dynamics Molecular Dynamics Simulation Oxygen Physics Protein Structure, Secondary Qualitative analysis Substrate Specificity Thermodynamics X-ray crystallography
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