$Actin filaments at the leading edge of cancer cells are characterized by a high mobile fraction and turnover regulation by profilin I$

Actin filaments at the leading edge of cancer cells are characterized by a high mobile fraction and turnover regulation by profilin I

Cellular motility is the basis for cancer cell invasion and metastasis. In the case of breast cancer, the most common type of cancer among women, metastasis represents the most devastating stage of the disease. The central role of cellular motility in cancer development emphasizes the importance of...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e85817-e85817
Hauptverfasser:	Lorente, Gisela, Syriani, Emilio, Morales, Miguel
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - metabolism Actins - metabolism Animals Binding proteins Biology Breast cancer Cancer Cancer cells Cancer metastasis Cell adhesion & migration Cell culture Cell Line, Tumor Cell migration Cell Movement Cell Size Cytoskeleton Defects Development and progression Elongation Extracellular Space - metabolism Female Filaments Fluorescence Fluorescence recovery after photobleaching Focal Adhesions Growth factors Humans Intercellular Signaling Peptides and Proteins - metabolism Intracellular levels Medicine Metastases Metastasis Mice Motility Muscle proteins Neoplasms - metabolism Neoplasms - pathology Photobleaching Polymerization Profilin Profilins - metabolism Protein binding Proteins Pseudopodia - metabolism Recovery (Medical) Time Factors Tumors Up-Regulation
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