Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition

β-Lactamases are the major reason β-lactam resistance is seen in Gram-negative bacteria. To combat this resistance mechanism, β-lactamase inhibitors are currently being developed. Presently, there are only three that are in clinical use (clavulanate, sulbactam and tazobactam). In order to address th...

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Veröffentlicht in:	PloS one 2014, Vol.9 (1), p.e85892
Hauptverfasser:	Rodkey, Elizabeth A, Winkler, Marisa L, Bethel, Christopher R, Pagadala, Sundar Ram Reddy, Buynak, John D, Bonomo, Robert A, van den Akker, Focco
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Amino Acid Substitution Analogs Anti-Bacterial Agents - chemistry Antibiotics Bacteria Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry beta-Lactam Resistance beta-Lactamase Inhibitors beta-Lactamases - chemistry beta-Lactamases - genetics Biochemistry Biology Catalytic Domain Chains Chemistry Crystallography Crystallography, X-Ray Deacylation Design Enzymes Gram-negative bacteria Heterocyclic Compounds, 2-Ring - chemistry Inhibition Kinetics Ligands Materials Science Medicine Models, Molecular Molecular biology Mutagenesis Penicillanic Acid - analogs & derivatives Penicillanic Acid - chemistry Protein Binding Structure-Activity Relationship Sulbactam Sulfones Sulfones - chemistry Synthesis Tazobactam Thiazolidines - chemistry Veterans
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