Relationship between changes in body fat and a decline of renal function in the elderly
Obesity is a risk factor for chronic kidney disease, and its prevalence among the elderly is increasing. We investigated the effects of changes in body fat percentage (BFP) on the longitudinal changes in the estimated glomerular filtration rate (eGFR) in the elderly. This prospective cohort study in...
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| creator | Oh, Se Won Ahn, Shin Young Jianwei, Xu Kim, Ki Woong Kim, Sejoong Na, Ki Young Chae, Dong Wan Kim, Suhnggwon Chin, Ho Jun |
| description | Obesity is a risk factor for chronic kidney disease, and its prevalence among the elderly is increasing. We investigated the effects of changes in body fat percentage (BFP) on the longitudinal changes in the estimated glomerular filtration rate (eGFR) in the elderly. This prospective cohort study included 390 participants aged >65 years who underwent bioelectrical impedance analysis at baseline and follow-up as a part of the Korean Longitudinal Study on Health and Aging. After a median follow-up period of 5.3 years, BFP was significantly higher than that at the start point (P |
| doi_str_mv | 10.1371/journal.pone.0084052 |
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We investigated the effects of changes in body fat percentage (BFP) on the longitudinal changes in the estimated glomerular filtration rate (eGFR) in the elderly. This prospective cohort study included 390 participants aged >65 years who underwent bioelectrical impedance analysis at baseline and follow-up as a part of the Korean Longitudinal Study on Health and Aging. After a median follow-up period of 5.3 years, BFP was significantly higher than that at the start point (P<0.05). Participants who had the largest increase in BFP had the highest BMI and waist circumference (WC) (P<0.001). The highest tertile had the highest white blood cell count and erythrocyte sedimentation rate, incidence of rapid progression, and decline in eGFR >25% (P≤0.017, P = 0.025, P = 0.005, respectively). The lowest tertile had the lowest triglyceride and highest high-density lipoprotein levels (P<0.05). The adjusted decline rate in eGFR was correlated with a change in BFP (P = 0.039), but not with that in BMI or WC. The highest tertile had a 4.875-fold increase in the risk for rapid progression to a decline in eGFR (95% CI: 1.366-17.397) and a 4.931-fold decrease in the risk to a decline in eGFR>25% (95% CI: 1.617-15.037), when compared with the lowest tertile. In subgroup analysis, the incidence of renal outcomes was significantly increased according to the increase in BFP in patients with lower eGFR (P≤0.010). A change in BFP may be associated with inflammation and dyslipidemia development, and longitudinal changes in body fat are related to a decrease in eGFR in the elderly.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0084052</identifier><identifier>PMID: 24454716</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Aging ; Analysis ; Bioelectricity ; Body composition ; Body fat ; Body Fat Distribution ; Body mass ; Body mass index ; Cardiovascular disease ; Chronic kidney failure ; Correlation analysis ; Diabetes ; Dyslipidemia ; Epidermal growth factor receptors ; Erythrocyte sedimentation rate ; Erythrocytes ; Exercise ; Female ; Geriatrics ; Glomerular Filtration Rate ; Health risks ; Hospitals ; Humans ; Hypertension ; Incidence ; Inflammation ; Internal medicine ; Kidney - physiopathology ; Kidney diseases ; Kidney transplantation ; Leukocytes ; Male ; Medical research ; Medicine ; Mortality ; Obesity ; Older people ; Physical fitness ; Population ; Prospective Studies ; Renal function ; Risk factors ; Studies ; Waist-Hip Ratio</subject><ispartof>PloS one, 2014-01, Vol.9 (1), p.e84052-e84052</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Oh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Oh et al 2014 Oh et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-40aa9dcc29c1cee5e501c9d8d7ab13cf58cc015e987fa8dbb709404d6adddc053</citedby><cites>FETCH-LOGICAL-c758t-40aa9dcc29c1cee5e501c9d8d7ab13cf58cc015e987fa8dbb709404d6adddc053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894176/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894176/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24454716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Joles, Jaap A.</contributor><creatorcontrib>Oh, Se Won</creatorcontrib><creatorcontrib>Ahn, Shin Young</creatorcontrib><creatorcontrib>Jianwei, Xu</creatorcontrib><creatorcontrib>Kim, Ki Woong</creatorcontrib><creatorcontrib>Kim, Sejoong</creatorcontrib><creatorcontrib>Na, Ki Young</creatorcontrib><creatorcontrib>Chae, Dong Wan</creatorcontrib><creatorcontrib>Kim, Suhnggwon</creatorcontrib><creatorcontrib>Chin, Ho Jun</creatorcontrib><title>Relationship between changes in body fat and a decline of renal function in the elderly</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Obesity is a risk factor for chronic kidney disease, and its prevalence among the elderly is increasing. We investigated the effects of changes in body fat percentage (BFP) on the longitudinal changes in the estimated glomerular filtration rate (eGFR) in the elderly. This prospective cohort study included 390 participants aged >65 years who underwent bioelectrical impedance analysis at baseline and follow-up as a part of the Korean Longitudinal Study on Health and Aging. After a median follow-up period of 5.3 years, BFP was significantly higher than that at the start point (P<0.05). Participants who had the largest increase in BFP had the highest BMI and waist circumference (WC) (P<0.001). The highest tertile had the highest white blood cell count and erythrocyte sedimentation rate, incidence of rapid progression, and decline in eGFR >25% (P≤0.017, P = 0.025, P = 0.005, respectively). The lowest tertile had the lowest triglyceride and highest high-density lipoprotein levels (P<0.05). The adjusted decline rate in eGFR was correlated with a change in BFP (P = 0.039), but not with that in BMI or WC. The highest tertile had a 4.875-fold increase in the risk for rapid progression to a decline in eGFR (95% CI: 1.366-17.397) and a 4.931-fold decrease in the risk to a decline in eGFR>25% (95% CI: 1.617-15.037), when compared with the lowest tertile. In subgroup analysis, the incidence of renal outcomes was significantly increased according to the increase in BFP in patients with lower eGFR (P≤0.010). A change in BFP may be associated with inflammation and dyslipidemia development, and longitudinal changes in body fat are related to a decrease in eGFR in the elderly.</description><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Analysis</subject><subject>Bioelectricity</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Body Fat Distribution</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Chronic kidney failure</subject><subject>Correlation analysis</subject><subject>Diabetes</subject><subject>Dyslipidemia</subject><subject>Epidermal growth factor receptors</subject><subject>Erythrocyte sedimentation rate</subject><subject>Erythrocytes</subject><subject>Exercise</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Glomerular Filtration Rate</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Inflammation</subject><subject>Internal medicine</subject><subject>Kidney - physiopathology</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Older people</subject><subject>Physical fitness</subject><subject>Population</subject><subject>Prospective Studies</subject><subject>Renal function</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Waist-Hip Ratio</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QDgujFjEmbJs2NsCx-DCwsrF-XIU1Opxkyydi06vx7053uMpW9kF6kJM_7npyTN8ueE7wkBSfvNmHovHLLXfCwxLiiuMwfZKdEFPmC5bh4ePR_kj2JcYNxWVSMPc5OckpLygk7zX5cg1O9DT62dodq6H8DeKRb5dcQkfWoDmaPGtUj5Q1SyIB21gMKDeoglUfN4PWoH9m-BQTOQOf2T7NHjXIRnk3rWfbt44evF58Xl1efVhfnlwvNy6pfUKyUMFrnQhMNUEKJiRamMlzVpNBNWWmNSQmi4o2qTF1zLCimhiljjE79nGUvD747F6KcZhIloZwLxnKRJ2J1IExQG7nr7FZ1exmUlTcboVtL1fVWO5DANFOiwAXwKhmYqhYl51rklGhckCZ5vZ-qDfUWjAbfd8rNTOcn3rZyHX7JohKUcJYM3kwGXfg5QOzl1kYNzikPYRjvLXIm8vQ4CX31D3p_dxO1VqkB65uQ6urRVJ5TXlUsL9jotbyHSp-BrdUpQI1N-zPB25kgMT386ddqiFGuvlz_P3v1fc6-PmJbUK5vY3DDTQLnID2AugsxdtDcDZlgOeb_dhpyzL-c8p9kL44f6E50G_jiLzfuABg</recordid><startdate>20140116</startdate><enddate>20140116</enddate><creator>Oh, Se Won</creator><creator>Ahn, Shin Young</creator><creator>Jianwei, Xu</creator><creator>Kim, Ki Woong</creator><creator>Kim, Sejoong</creator><creator>Na, Ki Young</creator><creator>Chae, Dong Wan</creator><creator>Kim, Suhnggwon</creator><creator>Chin, Ho Jun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140116</creationdate><title>Relationship between changes in body fat and a decline of renal function in the elderly</title><author>Oh, Se Won ; Ahn, Shin Young ; Jianwei, Xu ; Kim, Ki Woong ; Kim, Sejoong ; Na, Ki Young ; Chae, Dong Wan ; Kim, Suhnggwon ; Chin, Ho Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-40aa9dcc29c1cee5e501c9d8d7ab13cf58cc015e987fa8dbb709404d6adddc053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aging</topic><topic>Analysis</topic><topic>Bioelectricity</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Body Fat Distribution</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Chronic kidney failure</topic><topic>Correlation analysis</topic><topic>Diabetes</topic><topic>Dyslipidemia</topic><topic>Epidermal growth factor receptors</topic><topic>Erythrocyte sedimentation rate</topic><topic>Erythrocytes</topic><topic>Exercise</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Glomerular Filtration Rate</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Inflammation</topic><topic>Internal medicine</topic><topic>Kidney - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Se Won</au><au>Ahn, Shin Young</au><au>Jianwei, Xu</au><au>Kim, Ki Woong</au><au>Kim, Sejoong</au><au>Na, Ki Young</au><au>Chae, Dong Wan</au><au>Kim, Suhnggwon</au><au>Chin, Ho Jun</au><au>Joles, Jaap A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between changes in body fat and a decline of renal function in the elderly</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-01-16</date><risdate>2014</risdate><volume>9</volume><issue>1</issue><spage>e84052</spage><epage>e84052</epage><pages>e84052-e84052</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Obesity is a risk factor for chronic kidney disease, and its prevalence among the elderly is increasing. We investigated the effects of changes in body fat percentage (BFP) on the longitudinal changes in the estimated glomerular filtration rate (eGFR) in the elderly. This prospective cohort study included 390 participants aged >65 years who underwent bioelectrical impedance analysis at baseline and follow-up as a part of the Korean Longitudinal Study on Health and Aging. After a median follow-up period of 5.3 years, BFP was significantly higher than that at the start point (P<0.05). Participants who had the largest increase in BFP had the highest BMI and waist circumference (WC) (P<0.001). The highest tertile had the highest white blood cell count and erythrocyte sedimentation rate, incidence of rapid progression, and decline in eGFR >25% (P≤0.017, P = 0.025, P = 0.005, respectively). The lowest tertile had the lowest triglyceride and highest high-density lipoprotein levels (P<0.05). The adjusted decline rate in eGFR was correlated with a change in BFP (P = 0.039), but not with that in BMI or WC. The highest tertile had a 4.875-fold increase in the risk for rapid progression to a decline in eGFR (95% CI: 1.366-17.397) and a 4.931-fold decrease in the risk to a decline in eGFR>25% (95% CI: 1.617-15.037), when compared with the lowest tertile. In subgroup analysis, the incidence of renal outcomes was significantly increased according to the increase in BFP in patients with lower eGFR (P≤0.010). A change in BFP may be associated with inflammation and dyslipidemia development, and longitudinal changes in body fat are related to a decrease in eGFR in the elderly.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24454716</pmid><doi>10.1371/journal.pone.0084052</doi><tpages>e84052</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aged Aging Analysis Bioelectricity Body composition Body fat Body Fat Distribution Body mass Body mass index Cardiovascular disease Chronic kidney failure Correlation analysis Diabetes Dyslipidemia Epidermal growth factor receptors Erythrocyte sedimentation rate Erythrocytes Exercise Female Geriatrics Glomerular Filtration Rate Health risks Hospitals Humans Hypertension Incidence Inflammation Internal medicine Kidney - physiopathology Kidney diseases Kidney transplantation Leukocytes Male Medical research Medicine Mortality Obesity Older people Physical fitness Population Prospective Studies Renal function Risk factors Studies Waist-Hip Ratio |
| title | Relationship between changes in body fat and a decline of renal function in the elderly |
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