Anoxia-reoxygenation regulates mitochondrial dynamics through the hypoxia response pathway, SKN-1/Nrf, and stomatin-like protein STL-1/SLP-2

Many aerobic organisms encounter oxygen-deprived environments and thus must have adaptive mechanisms to survive such stress. It is important to understand how mitochondria respond to oxygen deprivation given the critical role they play in using oxygen to generate cellular energy. Here we examine mit...

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Veröffentlicht in:	PLoS genetics 2013-12, Vol.9 (12), p.e1004063
Hauptverfasser:	Ghose, Piya, Park, Eun Chan, Tabakin, Alexandra, Salazar-Vasquez, Nathaly, Rongo, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobiosis - genetics Aerobiosis - physiology Animals Apoptosis Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Hypoxia - genetics Cell Hypoxia - physiology Deoxyribonucleic acid DNA Dynamins - metabolism Heart attacks Homeostasis Hypoxia Hypoxia - genetics Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondria - physiology Mitochondrial Dynamics - genetics Mitochondrial Proteins - genetics Neurons - cytology Neurons - metabolism Neurons - physiology NF-E2-Related Factor 1 - genetics NF-E2-Related Factor 1 - metabolism Organisms Oxidation-Reduction Oxidative stress Oxidative Stress - genetics Physiological aspects Physiological research Proteins Scholarships & fellowships Stem cells Stress response Transcription Factors - metabolism Tumors
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