Regulatory circuits that enable proliferation of the fungus Candida albicans in a mammalian host
The ability of C. albicans to colonize and proliferate in the GI tract has been studied in mice receiving antibiotics orally; while these animals are not natural hosts of C. albicans, they likely serve as reasonable proxies. Because transcription regulators are central elements within the gene net...
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The ability of C. albicans to colonize and proliferate in the GI tract has been studied in mice receiving antibiotics orally; while these animals are not natural hosts of C. albicans, they likely serve as reasonable proxies. Because transcription regulators are central elements within the gene network of any organism, the use of them as entry points to the dissection of this trait has proved an effective strategy. By contrast, many "textbook" genetic circuits--those that most scientists have grown used to--consist of simple, unidirectional relationships among their components, making their behavior more predictable. Because of the distinctly interwoven appearance of the C. albicans circuit, it is difficult to predict its behavior without extensive knowledge of the parameters (e.g., concentration of proteins, affinity constants, and the like). |
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The ability of C. albicans to colonize and proliferate in the GI tract has been studied in mice receiving antibiotics orally; while these animals are not natural hosts of C. albicans, they likely serve as reasonable proxies. Because transcription regulators are central elements within the gene network of any organism, the use of them as entry points to the dissection of this trait has proved an effective strategy. By contrast, many "textbook" genetic circuits--those that most scientists have grown used to--consist of simple, unidirectional relationships among their components, making their behavior more predictable. Because of the distinctly interwoven appearance of the C. albicans circuit, it is difficult to predict its behavior without extensive knowledge of the parameters (e.g., concentration of proteins, affinity constants, and the like).</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1003780</identifier><identifier>PMID: 24385896</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biomedical research ; Candida ; Candida albicans - genetics ; Candida albicans - growth & development ; Candida albicans - pathogenicity ; Candidiasis - microbiology ; Cell Proliferation ; Disease ; Fungi ; Gene expression ; Gene Regulatory Networks - physiology ; Genomes ; Health aspects ; Host-parasite relationships ; Host-Pathogen Interactions - genetics ; Host-Pathogen Interactions - immunology ; Human body ; Humans ; Infections ; Intestines - metabolism ; Intestines - microbiology ; Iron - metabolism ; Microbiological research ; Microbiota ; Microorganisms ; Pearls ; Physiological aspects ; Studies</subject><ispartof>PLoS pathogens, 2013-12, Vol.9 (12), p.e1003780-e1003780</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Pérez, Johnson 2013 Pérez, Johnson</rights><rights>2013 Pérez, Johnson. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Pérez JC, Johnson AD (2013) Regulatory Circuits That Enable Proliferation of the Fungus Candida albicans in a Mammalian Host. PLoS Pathog 9(12): e1003780. doi:10.1371/journal.ppat.1003780</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c703t-109e40db331ae457c76365738f8f082c52343e5792c4708efb025acd081f12703</citedby><cites>FETCH-LOGICAL-c703t-109e40db331ae457c76365738f8f082c52343e5792c4708efb025acd081f12703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868511/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868511/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24385896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez, J Christian</creatorcontrib><creatorcontrib>Johnson, Alexander D</creatorcontrib><title>Regulatory circuits that enable proliferation of the fungus Candida albicans in a mammalian host</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>
The ability of C. albicans to colonize and proliferate in the GI tract has been studied in mice receiving antibiotics orally; while these animals are not natural hosts of C. albicans, they likely serve as reasonable proxies. Because transcription regulators are central elements within the gene network of any organism, the use of them as entry points to the dissection of this trait has proved an effective strategy. By contrast, many "textbook" genetic circuits--those that most scientists have grown used to--consist of simple, unidirectional relationships among their components, making their behavior more predictable. Because of the distinctly interwoven appearance of the C. albicans circuit, it is difficult to predict its behavior without extensive knowledge of the parameters (e.g., concentration of proteins, affinity constants, and the like).</description><subject>Animals</subject><subject>Biomedical research</subject><subject>Candida</subject><subject>Candida albicans - genetics</subject><subject>Candida albicans - growth & development</subject><subject>Candida albicans - pathogenicity</subject><subject>Candidiasis - microbiology</subject><subject>Cell Proliferation</subject><subject>Disease</subject><subject>Fungi</subject><subject>Gene expression</subject><subject>Gene Regulatory Networks - physiology</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Host-parasite relationships</subject><subject>Host-Pathogen Interactions - genetics</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Human body</subject><subject>Humans</subject><subject>Infections</subject><subject>Intestines - metabolism</subject><subject>Intestines - microbiology</subject><subject>Iron - metabolism</subject><subject>Microbiological research</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Pearls</subject><subject>Physiological aspects</subject><subject>Studies</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqVkkuLFDEUhQtRnHH0H4gG3Oii26TyrI0wND4aBoVR1_FWKqlOU5W0SUqcf2-13TNMgxvJIuHmOyeXm1NVzwleEirJ222cUoBhudtBWRKMqVT4QXVOOKcLSSV7eO98Vj3JeYsxI5SIx9VZzajiqhHn1Y9r208DlJhukPHJTL5kVDZQkA3QDhbtUhy8swmKjwFFN19a5KbQTxmtIHS-AwRD6w2EjHxAgEYYRxg8BLSJuTytHjkYsn123C-q7x_ef1t9Wlx9-bheXV4tjMS0LAhuLMNdSykBy7g0UlDBJVVOOaxqw2vKqOWyqQ2TWFnX4pqD6bAijtSzxUX18uC7G2LWx-FkTZiUDZMUi5lYH4guwlbvkh8h3egIXv8txNRrSMWbweqGcOYstAScY23TNYoJQzrhpBAtsc3s9e742tSOtjM2lATDienpTfAb3cdfmiqhOCGzweujQYo_J5uLHn02dhgg2Djt-26waERN1Iy-OqA9zK354OLsaPa4vqRc8qZmfE8t_0HNq7OjNzFY5-f6ieDNiWBmiv1dephy1uuv1__Bfj5l2YE1KeacrLubCsF6n9zbz9H75OpjcmfZi_sTvRPdRpX-AQRC6gI</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Pérez, J Christian</creator><creator>Johnson, Alexander D</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131201</creationdate><title>Regulatory circuits that enable proliferation of the fungus Candida albicans in a mammalian host</title><author>Pérez, J Christian ; Johnson, Alexander D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c703t-109e40db331ae457c76365738f8f082c52343e5792c4708efb025acd081f12703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biomedical research</topic><topic>Candida</topic><topic>Candida albicans - genetics</topic><topic>Candida albicans - growth & development</topic><topic>Candida albicans - pathogenicity</topic><topic>Candidiasis - microbiology</topic><topic>Cell Proliferation</topic><topic>Disease</topic><topic>Fungi</topic><topic>Gene expression</topic><topic>Gene Regulatory Networks - physiology</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Host-parasite relationships</topic><topic>Host-Pathogen Interactions - genetics</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Human body</topic><topic>Humans</topic><topic>Infections</topic><topic>Intestines - metabolism</topic><topic>Intestines - microbiology</topic><topic>Iron - metabolism</topic><topic>Microbiological research</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Pearls</topic><topic>Physiological aspects</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pérez, J Christian</creatorcontrib><creatorcontrib>Johnson, Alexander D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez, J Christian</au><au>Johnson, Alexander D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulatory circuits that enable proliferation of the fungus Candida albicans in a mammalian host</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>9</volume><issue>12</issue><spage>e1003780</spage><epage>e1003780</epage><pages>e1003780-e1003780</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>
The ability of C. albicans to colonize and proliferate in the GI tract has been studied in mice receiving antibiotics orally; while these animals are not natural hosts of C. albicans, they likely serve as reasonable proxies. Because transcription regulators are central elements within the gene network of any organism, the use of them as entry points to the dissection of this trait has proved an effective strategy. By contrast, many "textbook" genetic circuits--those that most scientists have grown used to--consist of simple, unidirectional relationships among their components, making their behavior more predictable. Because of the distinctly interwoven appearance of the C. albicans circuit, it is difficult to predict its behavior without extensive knowledge of the parameters (e.g., concentration of proteins, affinity constants, and the like).</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24385896</pmid><doi>10.1371/journal.ppat.1003780</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biomedical research Candida Candida albicans - genetics Candida albicans - growth & development Candida albicans - pathogenicity Candidiasis - microbiology Cell Proliferation Disease Fungi Gene expression Gene Regulatory Networks - physiology Genomes Health aspects Host-parasite relationships Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Human body Humans Infections Intestines - metabolism Intestines - microbiology Iron - metabolism Microbiological research Microbiota Microorganisms Pearls Physiological aspects Studies |
| title | Regulatory circuits that enable proliferation of the fungus Candida albicans in a mammalian host |
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