Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism

Tuberculosis is a current major world-health problem, exacerbated by the causative pathogen, Mycobacterium tuberculosis (Mtb), becoming increasingly resistant to conventional antibiotic treatment. Mtb is able to counteract the bactericidal mechanisms of leukocytes to survive intracellularly and deve...

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Veröffentlicht in:	PLoS pathogens 2013-12, Vol.9 (12), p.e1003789-e1003789
Hauptverfasser:	Elks, Philip M, Brizee, Sabrina, van der Vaart, Michiel, Walmsley, Sarah R, van Eeden, Fredericus J, Renshaw, Stephen A, Meijer, Annemarie H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Bacterial infections Basic Helix-Loop-Helix Transcription Factors - physiology Cells, Cultured Colleges & universities Disease Models, Animal Drug resistance Genetic Predisposition to Disease Health aspects Host-parasite relationships Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - physiology Microbiological research Mutagenesis Mycobacteria Mycobacterium Mycobacterium Infections, Nontuberculous - genetics Mycobacterium Infections, Nontuberculous - immunology Mycobacterium Infections, Nontuberculous - microbiology Mycobacterium marinum Neutrophils - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - physiology Nitrosation Pathogenesis Phenols Physiological aspects Rodents Signal Transduction - genetics Tuberculosis Zebrafish
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