Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry

The enveloped alphaviruses include important and emerging human pathogens such as Chikungunya virus and Eastern equine encephalitis virus. Alphaviruses enter cells by clathrin-mediated endocytosis, and exit by budding from the plasma membrane. While there has been considerable progress in defining t...

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Veröffentlicht in:	PLoS pathogens 2013-12, Vol.9 (12), p.e1003835
Hauptverfasser:	Ooi, Yaw Shin, Stiles, Katie M, Liu, Catherine Y, Taylor, Gwen M, Kielian, Margaret
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Alphavirus - physiology Alphavirus Infections - genetics Alphavirus Infections - virology Animals Biosynthesis Cells, Cultured Chikungunya virus - physiology Cricetinae Cytoplasm Endocytosis Endocytosis - drug effects Endocytosis - genetics Experiments Genome, Human Genome-wide association studies Genomes Health aspects HeLa Cells Host-Pathogen Interactions - drug effects Host-Pathogen Interactions - genetics Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - virology Humans Infections Medical research Microscopy Physiological aspects Proteins RNA Interference RNA viruses RNA, Small Interfering - genetics Semliki forest virus - physiology Sindbis Virus - physiology Transcriptome Viral genetics Virus Internalization Viruses
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