An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients

The possibility of HIV-1 eradication has been limited by the existence of latently infected cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have been hindered by the small numbers of latently infected cells found in vivo. Major conceptual leaps have been fac...

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Veröffentlicht in:	PLoS pathogens 2013-12, Vol.9 (12), p.e1003834-e1003834
Hauptverfasser:	Spina, Celsa A, Anderson, Jenny, Archin, Nancie M, Bosque, Alberto, Chan, Jonathan, Famiglietti, Marylinda, Greene, Warner C, Kashuba, Angela, Lewin, Sharon R, Margolis, David M, Mau, Matthew, Ruelas, Debbie, Saleh, Suha, Shirakawa, Kotaro, Siliciano, Robert F, Singhania, Akul, Soto, Paula C, Terry, Valeri H, Verdin, Eric, Woelk, Christopher, Wooden, Stacey, Xing, Sifei, Planelles, Vicente
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Acquired immune deficiency syndrome Adult AIDS CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - virology Cell research Cells, Cultured Health aspects HEK293 Cells Histone Deacetylase Inhibitors - pharmacology HIV (Viruses) HIV Infections - immunology HIV Infections - pathology HIV Infections - virology HIV-1 - drug effects HIV-1 - physiology Host-parasite relationships Humans Hydroxamic Acids - pharmacology Interleukin-7 - pharmacology Jurkat Cells Kinases Lymphocytes Medical research Models, Biological Patients Physiological aspects Studies T cells Veterans Virus Activation - drug effects Virus Latency - drug effects Vorinostat
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