Corticosteroids for dengue - why don't they work?
Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between hi...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2013-12, Vol.7 (12), p.e2592-e2592 |
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| creator | Nguyen, Thi Hanh Tien Nguyen, Than Ha Quyen Vu, Tuan Trung Farrar, Jeremy Hoang, Truong Long Dong, Thi Hoai Tam Ngoc Tran, Van Phung, Khanh Lam Wolbers, Marcel Whitehead, Stephen S Hibberd, Martin L Wills, Bridget Simmons, Cameron P |
| description | Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.
In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.
The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue. |
| doi_str_mv | 10.1371/journal.pntd.0002592 |
| format | Article |
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In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.
The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0002592</identifier><identifier>PMID: 24349598</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Child ; Child, Preschool ; Confidence intervals ; Corticosteroids ; Cytokines ; Cytokines - blood ; Dengue ; Dengue - drug therapy ; Dengue fever ; Disease ; Drug therapy ; Experiments ; Female ; Gene expression ; Gene Expression Profiling ; Genetic aspects ; Health aspects ; Hospitals ; Humans ; Illnesses ; Immunologic Factors - therapeutic use ; Immunomodulation ; Killer Cells, Natural - immunology ; Male ; Pathogenesis ; Patients ; Pediatrics ; Permeability ; Placebos - administration & dosage ; Prednisolone - therapeutic use ; Risk factors ; T-Lymphocytes, Cytotoxic - immunology ; Treatment Failure ; Tropical diseases ; Vietnam ; Young Adult</subject><ispartof>PLoS neglected tropical diseases, 2013-12, Vol.7 (12), p.e2592-e2592</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013</rights><rights>2013 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Citation: Nguyen THT, Nguyen THQ, Vu TT, Farrar J, Hoang TL, et al. (2013) Corticosteroids for Dengue - Why Don't They Work? PLoS Negl Trop Dis 7(12): e2592. doi:10.1371/journal.pntd.0002592</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-53bd97e8e3bc5f4616298d40fdfe94c630e070035a0c1b1af758c5d44fb7811c3</citedby><cites>FETCH-LOGICAL-c590t-53bd97e8e3bc5f4616298d40fdfe94c630e070035a0c1b1af758c5d44fb7811c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861232/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861232/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24349598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Thi Hanh Tien</creatorcontrib><creatorcontrib>Nguyen, Than Ha Quyen</creatorcontrib><creatorcontrib>Vu, Tuan Trung</creatorcontrib><creatorcontrib>Farrar, Jeremy</creatorcontrib><creatorcontrib>Hoang, Truong Long</creatorcontrib><creatorcontrib>Dong, Thi Hoai Tam</creatorcontrib><creatorcontrib>Ngoc Tran, Van</creatorcontrib><creatorcontrib>Phung, Khanh Lam</creatorcontrib><creatorcontrib>Wolbers, Marcel</creatorcontrib><creatorcontrib>Whitehead, Stephen S</creatorcontrib><creatorcontrib>Hibberd, Martin L</creatorcontrib><creatorcontrib>Wills, Bridget</creatorcontrib><creatorcontrib>Simmons, Cameron P</creatorcontrib><title>Corticosteroids for dengue - why don't they work?</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.
In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.
The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Confidence intervals</subject><subject>Corticosteroids</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Dengue</subject><subject>Dengue - drug therapy</subject><subject>Dengue fever</subject><subject>Disease</subject><subject>Drug therapy</subject><subject>Experiments</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Immunomodulation</subject><subject>Killer Cells, Natural - immunology</subject><subject>Male</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Permeability</subject><subject>Placebos - administration & dosage</subject><subject>Prednisolone - therapeutic use</subject><subject>Risk factors</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Treatment Failure</subject><subject>Tropical diseases</subject><subject>Vietnam</subject><subject>Young Adult</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNkkuP0zAUhS0EYobCP0AQCWlg0-JnHG9Ao4rHSCOxgbXl2NdNShoX22HUfz8JzYzaHQvLlv3dc32uDkKvCV4RJsnHbRhib7rVvs9uhTGmQtEn6JIoJpZUMvH05HyBXqS0xVgoUZHn6IJyxpVQ1SUi6xBza0PKEEPrUuFDLBz0mwGKZXHXHAoX-ve5yA0cirsQf39-iZ550yV4Ne8L9Ovrl5_r78vbH99u1te3SysUzkvBaqckVMBqKzwvSUlV5Tj2zoPitmQYsMSYCYMtqYnxUlRWOM59LStCLFugt0fdfReSnt0mTbiUijM2rgW6ORIumK3ex3Zn4kEH0-p_FyFutJnMdaBNXUnvlQdWes4orcETYjAxVDFOvRy1Ps3dhnoHzkKfo-nORM9f-rbRm_BXs6oklNFR4MMsEMOfAVLWuzZZ6DrTQximfytaciwY_w-0VKUQgpcj-u6Ibszoou19GJvbCdfXTMhJUeKRujqhGjBdblLohtyGPp2D_AjaGFKK4B8NEqynVD3MWU-p0nOqxrI3p8N5LHqIEbsHF0LH3Q</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Nguyen, Thi Hanh Tien</creator><creator>Nguyen, Than Ha Quyen</creator><creator>Vu, Tuan Trung</creator><creator>Farrar, Jeremy</creator><creator>Hoang, Truong Long</creator><creator>Dong, Thi Hoai Tam</creator><creator>Ngoc Tran, Van</creator><creator>Phung, Khanh Lam</creator><creator>Wolbers, Marcel</creator><creator>Whitehead, Stephen S</creator><creator>Hibberd, Martin L</creator><creator>Wills, Bridget</creator><creator>Simmons, Cameron P</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131201</creationdate><title>Corticosteroids for dengue - why don't they work?</title><author>Nguyen, Thi Hanh Tien ; 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In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.
The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24349598</pmid><doi>10.1371/journal.pntd.0002592</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Child Child, Preschool Confidence intervals Corticosteroids Cytokines Cytokines - blood Dengue Dengue - drug therapy Dengue fever Disease Drug therapy Experiments Female Gene expression Gene Expression Profiling Genetic aspects Health aspects Hospitals Humans Illnesses Immunologic Factors - therapeutic use Immunomodulation Killer Cells, Natural - immunology Male Pathogenesis Patients Pediatrics Permeability Placebos - administration & dosage Prednisolone - therapeutic use Risk factors T-Lymphocytes, Cytotoxic - immunology Treatment Failure Tropical diseases Vietnam Young Adult |
| title | Corticosteroids for dengue - why don't they work? |
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