Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway

Platelets play a pivotal role in atherothrombosis and the antiplatelet agents have been proved to be useful in preventing onset of acute clinical events including myocardial infarction and stroke. Increasing number of natural compounds has been identified to be potential antiplatelet agents. Here we...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e85120-e85120
Hauptverfasser:	Li, Wei, Tang, Xiaorong, Yi, Wenxiu, Li, Qiang, Ren, Lijie, Liu, Xiaohui, Chu, Chunjun, Ozaki, Yukio, Zhang, Jian, Zhu, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Activation Adenosine diphosphate Adenosine Diphosphate - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antiplatelet therapy Apoptosis Bleeding Blood clots Blood Coagulation - drug effects Blood platelets Blood Platelets - metabolism Cerebral infarction Chinese medicine Chromatography Collagen Collagen - pharmacology Cytotoxicity Diterpenes, Kaurane - chemistry Diterpenes, Kaurane - isolation & purification Diterpenes, Kaurane - pharmacology Heart attack Hematology Humans In vivo methods and tests Inhibition Integrins Isodon - chemistry Kinases Leukemia Ligands Male Mice Molecular modelling Myocardial infarction Occlusion P-selectin Peripheral blood Pharmaceutical sciences Phospholipase Phospholipase C Phosphorylation Platelet Adhesiveness - drug effects Platelet aggregation Platelet Membrane Glycoproteins - metabolism Platelets Secretion Signal Transduction Signaling Syk protein Thrombin Thrombosis Tyrosine Vasoconstrictor Agents - pharmacology
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