Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function

Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, "high-risk" HPV E6 proteins bind to and modify the target...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e84506-e84506
Hauptverfasser:	Cherry, Jonathan J, Rietz, Anne, Malinkevich, Anna, Liu, Yuqi, Xie, Meng, Bartolowits, Matthew, Davisson, V Jo, Baleja, James D, Androphy, Elliot J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antiviral agents Assaying Binding Biochemistry Cell activation Cell cycle Cell proliferation Cervical cancer Cervix Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - metabolism Dermatology Docking Drug Discovery Female Flavones Flavonoids Flavonoids - antagonists & inhibitors Flavonoids - chemistry Flavonoids - pharmacology Health aspects High-Throughput Screening Assays - methods Human papillomavirus Human papillomavirus 16 - drug effects Humans Hydrophobicity Isoflavones Luteolin - pharmacology Medical schools Medicine Models, Molecular Molecular Structure Oncogene Proteins, Viral - chemistry Oncogene Proteins, Viral - metabolism p53 Protein Papillomavirus Papillomavirus infections Pharmaceutical sciences Pharmacy Protein binding Protein Binding - physiology Proteins Replication Repressor Proteins - chemistry Repressor Proteins - metabolism Senescence Structural analysis Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism Tumorigenesis Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - virology Viability Viruses
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