Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice

Microglia of the central nervous system act as sentinels and rapidly react to infection or inflammation. The pathophysiological role of bone marrow-derived microglia is of particular interest because they affect neurodegenerative disorders and neuropathic pain. The hypothesis of the current study is...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81744-e81744
Hauptverfasser:	Ataka, Koji, Asakawa, Akihiro, Nagaishi, Kanna, Kaimoto, Kaori, Sawada, Atsushi, Hayakawa, Yuko, Tatezawa, Ryota, Inui, Akio, Fujimiya, Mineko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Alzheimer's disease Amyotrophic lateral sclerosis Animals Bone marrow Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Brain CC chemokine receptors CCR2 protein Central nervous system Chemokine CCL2 - metabolism Chemokine CXCL12 - metabolism Chemotaxis - immunology CXCR4 protein Cytokines Hypothalamus Hypothalamus - immunology Hypothalamus - metabolism Hypothalamus - pathology IL-1β Infiltration Inflammation Interleukin-1beta - metabolism Interleukins Internal medicine Irritable bowel syndrome Male Medical research Medicine Metastases Mice Microglia Microglia - immunology Microglia - metabolism Microglia - pathology Monocyte chemoattractant protein 1 Monocytes Motility Neurodegeneration Neurodegenerative diseases Neurons - metabolism Neuropathy Neurosciences Nuclei Pain Paraventricular Hypothalamic Nucleus - immunology Paraventricular Hypothalamic Nucleus - metabolism Paraventricular Hypothalamic Nucleus - pathology Paraventricular nucleus Peripheral circulation Peripheral neuropathy Proteins Psychological stress Receptors, CCR2 - metabolism Receptors, CXCR4 - metabolism Receptors, Interleukin-1 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Recruitment RNA, Messenger - genetics Rodents SDF-1 protein Stem cell transplantation Stem cells Stress, Psychological - genetics Stress, Psychological - immunology Stress, Psychological - metabolism Stress, Psychological - pathology Transgenic animals Tumor necrosis factor-α University graduates
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