Rare variant association testing by adaptive combination of P-values

Rare variant association testing by adaptive combination of P-values

With the development of next-generation sequencing technology, there is a great demand for powerful statistical methods to detect rare variants (minor allele frequencies (MAFs)

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Bibliographische Detailangaben
Veröffentlicht in:PloS one 2014-01, Vol.9 (1), p.e85728-e85728
Hauptverfasser: Lin, Wan-Yu, Lou, Xiang-Yang, Gao, Guimin, Liu, Nianjun
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Analysis
Biology
Case-Control Studies
Computer Simulation
Data analysis
Data Interpretation, Statistical
Data processing
Gene Frequency
Genetic Association Studies - methods
Genomes
Haplotypes
Health care
Heart Diseases - genetics
High-Throughput Nucleotide Sequencing
Humans
Linear Models
Mathematics
Medical tests
Medicine
Methods
Models, Genetic
Noise
Polymorphism, Single Nucleotide
Power
Random variables
Sequence Analysis, DNA
Software
Statistical methods
Studies
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Beschreibung
Zusammenfassung:With the development of next-generation sequencing technology, there is a great demand for powerful statistical methods to detect rare variants (minor allele frequencies (MAFs)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0085728