Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells

Perfluorooctane sulfonate (PFOS) is a synthetic material that has been widely used in industrial applications for decades. Exposure to PFOS has been associated with decreased adult testosterone level, and Leydig cell impairment during the time of adulthood. However, little is known about PFOS effect...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e78888
Hauptverfasser:	Zhao, Binghai, Li, Li, Liu, Jieting, Li, Hongzhi, Zhang, Chunlei, Han, Pengfei, Zhang, Yufei, Yuan, Xiaohuan, Ge, Ren Shan, Chu, Yanhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanesulfonic Acids - toxicity Androgens Animals Apoptosis Apoptosis - drug effects Biology Blood & organ donations Blood cholesterol Cancer Cell Count Cell Size - drug effects Cholesterol Cholesterol - metabolism Dehydrogenases Endocrine disruptors Endocrinology Exposure Female Fetus - cytology Fetus - drug effects Fetus - physiology Fetuses Fluorocarbons - toxicity Gene expression Gene Expression Regulation - drug effects Impairment Industrial applications Laboratory animals Leydig cells Leydig Cells - drug effects Male Maternal Exposure - adverse effects Medicine Perfluorooctane sulfonic acid Potassium Pregnancy Production management Rats Rats, Sprague-Dawley Reproduction - drug effects Reproductive system Rodents Studies Surface active agents Testosterone Testosterone - biosynthesis Ultrastructure
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