Physical status of human papillomavirus integration in cervical cancer is associated with treatment outcome of the patients treated with radiotherapy

Integration of human papillomavirus (HPV) DNA into the host genome is a critical aetiological event in the progression from normal cervix to intraepithelial neoplasm, and finally to invasive cervical cancer. However, there has been little work on how HPV integration status relates to treatment outco...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e78995-e78995
Hauptverfasser:	Shin, Hye-Jin, Joo, Jungnam, Yoon, Ji Hyun, Yoo, Chong Woo, Kim, Joo-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alphapapillomavirus - classification Alphapapillomavirus - genetics Biology Cancer Cancer research Cancer treatment Care and treatment Cell adhesion & migration Cervical cancer Cervical carcinoma Clinical outcomes Cluster Analysis Deoxyribonucleic acid Development and progression DNA DNA microarrays E6 gene Female Gene Dosage Gene expression Gene Expression Profiling Genes Genomes Hazards Health risks Human papillomavirus Humans Infections Integration Invasiveness Medical prognosis Medical research Medicine Middle Aged Models, Statistical Multivariate analysis Neoplasia Neoplasm Grading Neoplasm Recurrence, Local Neoplasm Staging NMR Nuclear magnetic resonance Oligonucleotides Oncogene Proteins, Viral - genetics Papillomavirus Papillomavirus infections Papillomavirus Infections - complications Patient outcomes Patients Prognosis Quality Radiation therapy Radiotherapy Reproducibility of Results Resampling Risk Factors Risk groups Squamous cell carcinoma Statistical models Tissues Tomography Treatment Outcome Tumors Uterine Cervical Neoplasms - mortality Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy Uterine Cervical Neoplasms - virology Virus Integration
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