SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1

Organisms exposed to oxidative stress respond by orchestrating a stress response to prevent further damage. Intracellular levels of antioxidant agents increase, and damaged components are removed by autophagy induction. The KEAP1-NRF2 signaling pathway is the main pathway responsible for cell defens...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e85262
Hauptverfasser:	Darvekar, Sagar Ramesh, Elvenes, Julianne, Brenne, Hanne Britt, Johansen, Terje, Sjøttem, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Anticarcinogenic Agents - pharmacology Antioxidants Antioxidants (Nutrients) Autophagy Autophagy - drug effects Biology Cancer Cell death Clinical medical disciplines: 750 Damage prevention Enzymes Gene expression Gene Expression Regulation, Neoplastic - drug effects Genes Genetic aspects HeLa Cells Humans Hypoxia Intracellular levels Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Isothiocyanate Isothiocyanates - pharmacology Kelch-Like ECH-Associated Protein 1 Klinisk medisinske fag: 750 Medical disciplines: 700 Medical research Medicine Medisinske Fag: 700 Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oncology: 762 Onkologi: 762 Oxidative stress Phagocytosis Physiological aspects Promoter Regions, Genetic Proteins Reporter gene RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Sequestosome-1 Protein Signal Transduction Signaling siRNA Sulforaphane Transcription Transcription (Genetics) Transcription factors Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic VDP Vegetables
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