Identification of an HLA-A2-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2)

We herein report the identification of an HLA-A2 supertype-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2), which is known to be a diagnostic marker and a potential therapeutic target for renal cell carcinoma. Among several candidate peptides predicted by the HLA-binding p...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e85267-e85267
Hauptverfasser:	Yoshimura, Sachiko, Tsunoda, Takuya, Osawa, Ryuji, Harada, Makiko, Watanabe, Tomohisa, Hikichi, Tetsuro, Katsuda, Masahiro, Miyazawa, Motoki, Tani, Masaji, Iwahashi, Makoto, Takeda, Kazuyoshi, Katagiri, Toyomasa, Nakamura, Yusuke, Yamaue, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigenic determinants Antigens Antigens, Neoplasm - chemistry Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Biological response modifiers Biology Cancer Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - pathology Cell Line, Tumor Clinical trials Cytotoxicity Diagnostic systems Epitopes Epitopes - chemistry Epitopes - genetics Epitopes - immunology Esophagus Gene Expression - immunology Genomes Health aspects Histocompatibility antigen HLA HLA antigens HLA-A2 Antigen - chemistry HLA-A2 Antigen - genetics HLA-A2 Antigen - immunology Humans Hypoxia Immunotherapy Interferon Interferon-gamma - biosynthesis Interferon-gamma - immunology Kidney cancer Kidney Neoplasms - genetics Kidney Neoplasms - immunology Kidney Neoplasms - pathology Kinases Laboratories Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T Lymphoma Medicine Melanoma Metastasis Molecular Sequence Data Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - immunology Peptides Peptides - chemistry Peptides - genetics Peptides - immunology Peptides - pharmacology Predictions Protein Binding Proteins R&D Renal cell carcinoma Research & development Science Surgery T cells T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology γ-Interferon
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