Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy

Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading to tissue ischemia and hypoxia, followed by sight threatening pathologic neov...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e85031
Hauptverfasser:	Michan, Shaday, Juan, Aimee M, Hurst, Christian G, Cui, Zhenghao, Evans, Lucy P, Hatton, Colman J, Pei, Dorothy T, Ju, Meihua, Sinclair, David A, Smith, Lois E H, Chen, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Aging Animals Biology Blindness Blood vessels Children Children & youth Crosses, Genetic Degeneration Diabetes Diabetes mellitus Diabetic retinopathy Diet Disease Disease Models, Animal Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Flox Gene Expression Heterocyclic Compounds, 4 or More Rings - pharmacology Hospitals Humans Hypoxia Integrases - genetics Integrases - metabolism Intermediate filament proteins Ischemia Kinases Laboratories Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Medical schools Medicine Mice Monocytes Neovascularization Neovascularization, Pathologic Nerve Degeneration - chemically induced Nerve Degeneration - genetics Nerve Degeneration - metabolism Nerve Degeneration - pathology Nestin Nestin - genetics Nestin - metabolism Neurons Neurons - drug effects Neurons - metabolism Neurons - pathology Overexpression Oxidative stress Oxygen Oxygen - adverse effects Pathogenesis Physiological aspects Premature birth Proteins Receptor, TIE-2 - genetics Receptor, TIE-2 - metabolism Regeneration Resveratrol Retina Retina - drug effects Retina - metabolism Retina - pathology Retinal Degeneration - chemically induced Retinal Degeneration - genetics Retinal Degeneration - metabolism Retinal Degeneration - pathology Retinopathy Rodents SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Stilbenes - pharmacology Vascularization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!