Contribution of the resting-state functional connectivity of the contralesional primary sensorimotor cortex to motor recovery after subcortical stroke
It remains uncertain if the contralesional primary sensorimotor cortex (CL_PSMC) contributes to motor recovery after stroke. Here we investigated longitudinal changes in the resting-state functional connectivity (rsFC) of the CL_PSMC and their association with motor recovery. Thirteen patients who h...
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description | It remains uncertain if the contralesional primary sensorimotor cortex (CL_PSMC) contributes to motor recovery after stroke. Here we investigated longitudinal changes in the resting-state functional connectivity (rsFC) of the CL_PSMC and their association with motor recovery. Thirteen patients who had experienced subcortical stroke underwent a series of resting-state fMRI and clinical assessments over a period of 1 year at 5 time points, i.e., within the first week, at 2 weeks, 1 month, 3 months, and 1 year after stroke onset. Thirteen age- and gender-matched healthy subjects were recruited as controls. The CL_PSMC was defined as a region centered at the voxel that had greatest activation during hand motion task. The dynamic changes in the rsFCs of the CL_PSMC within the whole brain were evaluated and correlated with the Motricity Index (MI) scores. Compared with healthy controls, the rsFCs of the CL_PSMC with the bilateral PSMC were initially decreased, then gradually increased, and finally restored to the normal level 1 year later. Moreover, the dynamic change in the inter-hemispheric rsFC between the bilateral PSMC in these patients was positively correlated with the MI scores. However, the intra-hemispheric rsFC of the CL_PSMC was not correlated with the MI scores. This study shows dynamic changes in the rsFCs of the CL_PSMC after stroke and suggests that the increased inter-hemispheric rsFC between the bilateral PSMC may facilitate motor recovery in stroke patients. However, generalization of our findings is limited by the small sample size of our study and needs to be confirmed. |
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Here we investigated longitudinal changes in the resting-state functional connectivity (rsFC) of the CL_PSMC and their association with motor recovery. Thirteen patients who had experienced subcortical stroke underwent a series of resting-state fMRI and clinical assessments over a period of 1 year at 5 time points, i.e., within the first week, at 2 weeks, 1 month, 3 months, and 1 year after stroke onset. Thirteen age- and gender-matched healthy subjects were recruited as controls. The CL_PSMC was defined as a region centered at the voxel that had greatest activation during hand motion task. The dynamic changes in the rsFCs of the CL_PSMC within the whole brain were evaluated and correlated with the Motricity Index (MI) scores. Compared with healthy controls, the rsFCs of the CL_PSMC with the bilateral PSMC were initially decreased, then gradually increased, and finally restored to the normal level 1 year later. Moreover, the dynamic change in the inter-hemispheric rsFC between the bilateral PSMC in these patients was positively correlated with the MI scores. However, the intra-hemispheric rsFC of the CL_PSMC was not correlated with the MI scores. This study shows dynamic changes in the rsFCs of the CL_PSMC after stroke and suggests that the increased inter-hemispheric rsFC between the bilateral PSMC may facilitate motor recovery in stroke patients. However, generalization of our findings is limited by the small sample size of our study and needs to be confirmed.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0084729</identifier><identifier>PMID: 24416273</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Basal Metabolism ; Behavior - physiology ; Biology ; Brain ; Brain mapping ; Cortex (motor) ; Cortex (somatosensory) ; Female ; Functional magnetic resonance imaging ; Humans ; Image Processing, Computer-Assisted ; Laboratories ; Magnetic Resonance Imaging ; Male ; Medical research ; Medicine ; Middle Aged ; Motor Activity - physiology ; Nerve Net - physiopathology ; Neural networks ; Patients ; Psychomotor Performance - physiology ; Recovery ; Recovery (Medical) ; Recovery of Function ; Stroke ; Stroke - metabolism ; Stroke - physiopathology ; Time Factors</subject><ispartof>PloS one, 2014-01, Vol.9 (1), p.e84729-e84729</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Xu et al 2014 Xu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-733a2195ff10967d02c5ddae3157110b51703e4303677547d4837573774593623</citedby><cites>FETCH-LOGICAL-c692t-733a2195ff10967d02c5ddae3157110b51703e4303677547d4837573774593623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885617/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885617/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24416273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wenderoth, Nicole</contributor><creatorcontrib>Xu, Huijuan</creatorcontrib><creatorcontrib>Qin, Wen</creatorcontrib><creatorcontrib>Chen, Hai</creatorcontrib><creatorcontrib>Jiang, Lin</creatorcontrib><creatorcontrib>Li, Kuncheng</creatorcontrib><creatorcontrib>Yu, Chunshui</creatorcontrib><title>Contribution of the resting-state functional connectivity of the contralesional primary sensorimotor cortex to motor recovery after subcortical stroke</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>It remains uncertain if the contralesional primary sensorimotor cortex (CL_PSMC) contributes to motor recovery after stroke. Here we investigated longitudinal changes in the resting-state functional connectivity (rsFC) of the CL_PSMC and their association with motor recovery. Thirteen patients who had experienced subcortical stroke underwent a series of resting-state fMRI and clinical assessments over a period of 1 year at 5 time points, i.e., within the first week, at 2 weeks, 1 month, 3 months, and 1 year after stroke onset. Thirteen age- and gender-matched healthy subjects were recruited as controls. The CL_PSMC was defined as a region centered at the voxel that had greatest activation during hand motion task. The dynamic changes in the rsFCs of the CL_PSMC within the whole brain were evaluated and correlated with the Motricity Index (MI) scores. Compared with healthy controls, the rsFCs of the CL_PSMC with the bilateral PSMC were initially decreased, then gradually increased, and finally restored to the normal level 1 year later. Moreover, the dynamic change in the inter-hemispheric rsFC between the bilateral PSMC in these patients was positively correlated with the MI scores. However, the intra-hemispheric rsFC of the CL_PSMC was not correlated with the MI scores. This study shows dynamic changes in the rsFCs of the CL_PSMC after stroke and suggests that the increased inter-hemispheric rsFC between the bilateral PSMC may facilitate motor recovery in stroke patients. However, generalization of our findings is limited by the small sample size of our study and needs to be confirmed.</description><subject>Adult</subject><subject>Basal Metabolism</subject><subject>Behavior - physiology</subject><subject>Biology</subject><subject>Brain</subject><subject>Brain mapping</subject><subject>Cortex (motor)</subject><subject>Cortex (somatosensory)</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Laboratories</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Nerve Net - physiopathology</subject><subject>Neural networks</subject><subject>Patients</subject><subject>Psychomotor Performance - physiology</subject><subject>Recovery</subject><subject>Recovery (Medical)</subject><subject>Recovery of Function</subject><subject>Stroke</subject><subject>Stroke - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Huijuan</au><au>Qin, Wen</au><au>Chen, Hai</au><au>Jiang, Lin</au><au>Li, Kuncheng</au><au>Yu, Chunshui</au><au>Wenderoth, Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of the resting-state functional connectivity of the contralesional primary sensorimotor cortex to motor recovery after subcortical stroke</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-01-08</date><risdate>2014</risdate><volume>9</volume><issue>1</issue><spage>e84729</spage><epage>e84729</epage><pages>e84729-e84729</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>It remains uncertain if the contralesional primary sensorimotor cortex (CL_PSMC) contributes to motor recovery after stroke. Here we investigated longitudinal changes in the resting-state functional connectivity (rsFC) of the CL_PSMC and their association with motor recovery. Thirteen patients who had experienced subcortical stroke underwent a series of resting-state fMRI and clinical assessments over a period of 1 year at 5 time points, i.e., within the first week, at 2 weeks, 1 month, 3 months, and 1 year after stroke onset. Thirteen age- and gender-matched healthy subjects were recruited as controls. The CL_PSMC was defined as a region centered at the voxel that had greatest activation during hand motion task. The dynamic changes in the rsFCs of the CL_PSMC within the whole brain were evaluated and correlated with the Motricity Index (MI) scores. Compared with healthy controls, the rsFCs of the CL_PSMC with the bilateral PSMC were initially decreased, then gradually increased, and finally restored to the normal level 1 year later. Moreover, the dynamic change in the inter-hemispheric rsFC between the bilateral PSMC in these patients was positively correlated with the MI scores. However, the intra-hemispheric rsFC of the CL_PSMC was not correlated with the MI scores. This study shows dynamic changes in the rsFCs of the CL_PSMC after stroke and suggests that the increased inter-hemispheric rsFC between the bilateral PSMC may facilitate motor recovery in stroke patients. However, generalization of our findings is limited by the small sample size of our study and needs to be confirmed.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24416273</pmid><doi>10.1371/journal.pone.0084729</doi><tpages>e84729</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Basal Metabolism Behavior - physiology Biology Brain Brain mapping Cortex (motor) Cortex (somatosensory) Female Functional magnetic resonance imaging Humans Image Processing, Computer-Assisted Laboratories Magnetic Resonance Imaging Male Medical research Medicine Middle Aged Motor Activity - physiology Nerve Net - physiopathology Neural networks Patients Psychomotor Performance - physiology Recovery Recovery (Medical) Recovery of Function Stroke Stroke - metabolism Stroke - physiopathology Time Factors |
title | Contribution of the resting-state functional connectivity of the contralesional primary sensorimotor cortex to motor recovery after subcortical stroke |
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