Brain metabolism during hallucination-like auditory stimulation in schizophrenia
Auditory verbal hallucinations (AVH) in schizophrenia are typically characterized by rich emotional content. Despite the prominent role of emotion in regulating normal perception, the neural interface between emotion-processing regions such as the amygdala and auditory regions involved in perception...
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| description | Auditory verbal hallucinations (AVH) in schizophrenia are typically characterized by rich emotional content. Despite the prominent role of emotion in regulating normal perception, the neural interface between emotion-processing regions such as the amygdala and auditory regions involved in perception remains relatively unexplored in AVH. Here, we studied brain metabolism using FDG-PET in 9 remitted patients with schizophrenia that previously reported severe AVH during an acute psychotic episode and 8 matched healthy controls. Participants were scanned twice: (1) at rest and (2) during the perception of aversive auditory stimuli mimicking the content of AVH. Compared to controls, remitted patients showed an exaggerated response to the AVH-like stimuli in limbic and paralimbic regions, including the left amygdala. Furthermore, patients displayed abnormally strong connections between the amygdala and auditory regions of the cortex and thalamus, along with abnormally weak connections between the amygdala and medial prefrontal cortex. These results suggest that abnormal modulation of the auditory cortex by limbic-thalamic structures might be involved in the pathophysiology of AVH and may potentially account for the emotional features that characterize hallucinatory percepts in schizophrenia. |
| doi_str_mv | 10.1371/journal.pone.0084987 |
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Despite the prominent role of emotion in regulating normal perception, the neural interface between emotion-processing regions such as the amygdala and auditory regions involved in perception remains relatively unexplored in AVH. Here, we studied brain metabolism using FDG-PET in 9 remitted patients with schizophrenia that previously reported severe AVH during an acute psychotic episode and 8 matched healthy controls. Participants were scanned twice: (1) at rest and (2) during the perception of aversive auditory stimuli mimicking the content of AVH. Compared to controls, remitted patients showed an exaggerated response to the AVH-like stimuli in limbic and paralimbic regions, including the left amygdala. Furthermore, patients displayed abnormally strong connections between the amygdala and auditory regions of the cortex and thalamus, along with abnormally weak connections between the amygdala and medial prefrontal cortex. These results suggest that abnormal modulation of the auditory cortex by limbic-thalamic structures might be involved in the pathophysiology of AVH and may potentially account for the emotional features that characterize hallucinatory percepts in schizophrenia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0084987</identifier><identifier>PMID: 24416328</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acoustic Stimulation ; Adult ; Al·lucinacions i il·lusions ; Amygdala ; Amygdala - diagnostic imaging ; Amygdala - metabolism ; Amygdala - physiopathology ; Amygdaloid body ; Auditory Cortex - diagnostic imaging ; Auditory Cortex - metabolism ; Auditory Cortex - physiopathology ; Auditory stimuli ; Biology ; Brain ; Brain Mapping ; Case-Control Studies ; Computer applications ; Cortex (auditory) ; Cos amigdaloide ; Dopamine ; Emotions ; Esquizofrènia ; Female ; Glucose - metabolism ; Hallucinations ; Hallucinations - diagnostic imaging ; Hallucinations - metabolism ; Hallucinations - physiopathology ; Hallucinations and illusions ; Hearing disorders ; Humans ; Hypotheses ; Implants ; Information processing ; Male ; Medical imaging ; Medical research ; Medicine ; Mental disorders ; Metabolism ; Mimicry ; Neurosciences ; Patients ; Perception ; Physiological aspects ; Positron emission tomography ; Prefrontal cortex ; Psychiatry ; Psychobiology ; Psychosis ; Remission Induction ; Schizophrenia ; Schizophrenia - diagnostic imaging ; Schizophrenia - metabolism ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Studies ; Thalamus ; Thalamus - diagnostic imaging ; Thalamus - metabolism ; Thalamus - physiopathology ; Tinnitus ; Tomografia ; Tomography ; Trastorns auditius</subject><ispartof>PloS one, 2014-01, Vol.9 (1), p.e84987-e84987</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Horga et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>cc-by (c) Horga, Guillermo et al., 2014 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a></rights><rights>2014 Horga et al 2014 Horga et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c734t-cacd1e83f3224e7c7b3a25ea442f27d83866148f55efebd27f39b237d2fc01bf3</citedby><cites>FETCH-LOGICAL-c734t-cacd1e83f3224e7c7b3a25ea442f27d83866148f55efebd27f39b237d2fc01bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885666/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885666/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,26979,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24416328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Stamatakis, Emmanuel Andreas</contributor><creatorcontrib>Horga, Guillermo</creatorcontrib><creatorcontrib>Fernández-Egea, Emilio</creatorcontrib><creatorcontrib>Mané, Anna</creatorcontrib><creatorcontrib>Font, Mireia</creatorcontrib><creatorcontrib>Schatz, Kelly C</creatorcontrib><creatorcontrib>Falcon, Carles</creatorcontrib><creatorcontrib>Lomeña, Francisco</creatorcontrib><creatorcontrib>Bernardo, Miguel</creatorcontrib><creatorcontrib>Parellada, Eduard</creatorcontrib><title>Brain metabolism during hallucination-like auditory stimulation in schizophrenia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Auditory verbal hallucinations (AVH) in schizophrenia are typically characterized by rich emotional content. Despite the prominent role of emotion in regulating normal perception, the neural interface between emotion-processing regions such as the amygdala and auditory regions involved in perception remains relatively unexplored in AVH. Here, we studied brain metabolism using FDG-PET in 9 remitted patients with schizophrenia that previously reported severe AVH during an acute psychotic episode and 8 matched healthy controls. Participants were scanned twice: (1) at rest and (2) during the perception of aversive auditory stimuli mimicking the content of AVH. Compared to controls, remitted patients showed an exaggerated response to the AVH-like stimuli in limbic and paralimbic regions, including the left amygdala. Furthermore, patients displayed abnormally strong connections between the amygdala and auditory regions of the cortex and thalamus, along with abnormally weak connections between the amygdala and medial prefrontal cortex. 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Academic</collection><collection>Recercat</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horga, Guillermo</au><au>Fernández-Egea, Emilio</au><au>Mané, Anna</au><au>Font, Mireia</au><au>Schatz, Kelly C</au><au>Falcon, Carles</au><au>Lomeña, Francisco</au><au>Bernardo, Miguel</au><au>Parellada, Eduard</au><au>Stamatakis, Emmanuel Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain metabolism during hallucination-like auditory stimulation in schizophrenia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-01-08</date><risdate>2014</risdate><volume>9</volume><issue>1</issue><spage>e84987</spage><epage>e84987</epage><pages>e84987-e84987</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Auditory verbal hallucinations (AVH) in schizophrenia are typically characterized by rich emotional content. Despite the prominent role of emotion in regulating normal perception, the neural interface between emotion-processing regions such as the amygdala and auditory regions involved in perception remains relatively unexplored in AVH. Here, we studied brain metabolism using FDG-PET in 9 remitted patients with schizophrenia that previously reported severe AVH during an acute psychotic episode and 8 matched healthy controls. Participants were scanned twice: (1) at rest and (2) during the perception of aversive auditory stimuli mimicking the content of AVH. Compared to controls, remitted patients showed an exaggerated response to the AVH-like stimuli in limbic and paralimbic regions, including the left amygdala. Furthermore, patients displayed abnormally strong connections between the amygdala and auditory regions of the cortex and thalamus, along with abnormally weak connections between the amygdala and medial prefrontal cortex. These results suggest that abnormal modulation of the auditory cortex by limbic-thalamic structures might be involved in the pathophysiology of AVH and may potentially account for the emotional features that characterize hallucinatory percepts in schizophrenia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24416328</pmid><doi>10.1371/journal.pone.0084987</doi><tpages>e84987</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1476179805 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); Recercat; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acoustic Stimulation Adult Al·lucinacions i il·lusions Amygdala Amygdala - diagnostic imaging Amygdala - metabolism Amygdala - physiopathology Amygdaloid body Auditory Cortex - diagnostic imaging Auditory Cortex - metabolism Auditory Cortex - physiopathology Auditory stimuli Biology Brain Brain Mapping Case-Control Studies Computer applications Cortex (auditory) Cos amigdaloide Dopamine Emotions Esquizofrènia Female Glucose - metabolism Hallucinations Hallucinations - diagnostic imaging Hallucinations - metabolism Hallucinations - physiopathology Hallucinations and illusions Hearing disorders Humans Hypotheses Implants Information processing Male Medical imaging Medical research Medicine Mental disorders Metabolism Mimicry Neurosciences Patients Perception Physiological aspects Positron emission tomography Prefrontal cortex Psychiatry Psychobiology Psychosis Remission Induction Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - metabolism Schizophrenia - physiopathology Schizophrenic Psychology Studies Thalamus Thalamus - diagnostic imaging Thalamus - metabolism Thalamus - physiopathology Tinnitus Tomografia Tomography Trastorns auditius |
| title | Brain metabolism during hallucination-like auditory stimulation in schizophrenia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T05%3A29%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Brain%20metabolism%20during%20hallucination-like%20auditory%20stimulation%20in%20schizophrenia&rft.jtitle=PloS%20one&rft.au=Horga,%20Guillermo&rft.date=2014-01-08&rft.volume=9&rft.issue=1&rft.spage=e84987&rft.epage=e84987&rft.pages=e84987-e84987&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0084987&rft_dat=%3Cgale_plos_%3EA478874301%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1476179805&rft_id=info:pmid/24416328&rft_galeid=A478874301&rft_doaj_id=oai_doaj_org_article_b72e5515fda2417b816b23dce80f2944&rfr_iscdi=true |